Citation: Yu-Han LI, Yu YANG, Hui-Chao GUAN, Min ZHANG, Lin-Lin XU, Shu-Mei YUE. Syntheses, Crystal Structures and DNA-binding Properties of Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) Complexes Containing Imidazolium Derivatives[J]. Chinese Journal of Structural Chemistry, ;2020, 39(2): 356-367. doi: 10.14102/j.cnki.0254–5861.2011–2633 shu

Syntheses, Crystal Structures and DNA-binding Properties of Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) Complexes Containing Imidazolium Derivatives

College of Chemistry, Changchun Normal University, Changchun 130032, China

Corresponding author: Shu-Mei YUE, 1620520613@qq.com
Received Date: 9 October 2019
Accepted Date: 27 November 2019

Figures(13)

Cd(Ⅱ), Co(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes (1~4) based on 2-(2-pyridyl)benzi-midazole (pbm) and 4, 4΄-oxybisbenzoic acid (H₂odc) were synthesized. The formulas of these complexes are [Cd(pbm)(odc)₂] (1), [Co(pbm)(odc)₂] (2), [Cu(pbm)(odc)₂] (3) and [Zn(pbm)(odc)₂] (4) confirmed by single-crystal X-ray diffraction analysis, which shows that complexes 1, 2 and 4 belong to monoclinic system with space group P2₁/n, while complex 3 belongs to monoclinic system with space group P2₁/c. The binding properties of complexes 1~4 with CT-DNA are evaluated by ultraviolet spectrum, fluorescence spectra and viscosity measurements. The results indicate that complexes 1~4 have strong interaction with CT-DNA binding. These complexes exhibit an electrostatic or groove mode in respect of binding with DNA, which can effectively destroy DNA. And this binding mode may be applied to the interaction between the complexes and cancer cell DNA. Therefore, we hope to provide a theoretical and scientific basis for the research of anti-cancer drugs.
- 2-(2-pyridyl)benzimidazole,
- crystal structure,
- CT-DNA binding
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