Citation: Dan Zhou, Xinyue Liu, Zijing Guo, Jianping Yang, Zeying Guo, Zhuoer Ren, E Yu, Ting Pan, Doudou Ren, Zhicong Zeng. Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)[J]. University Chemistry, ;2026, 41(6): 196-203. doi: 10.12461/PKU.DXHX202511180 shu

Development and teaching design of astigmatic displacement microscopy: a recommended experiment for chemical metrology (micro-nano advanced characterization)

Dan Zhou ¹ ,
Xinyue Liu ¹ ,
Zijing Guo ¹ ,
Jianping Yang ¹ ,
Zeying Guo ¹ ,
Zhuoer Ren ¹ ,
E Yu ² ,
Ting Pan ^1,, ,
Doudou Ren ^1,, ,
Zhicong Zeng ^1,,

1.
State Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, Gansu Province, China;
2.
National Demonstration Center for Experimental Chemistry Education (Lanzhou University), Lanzhou 730000, Gansu Province

Corresponding author: Ting Pan, Doudou Ren, Zhicong Zeng,
Received Date: 25 November 2025
Revised Date: 6 February 2026

In current undergraduate laboratory curricula concerning micro-nano characterization, scanning probe microscopy and scanning electron microscopy are predominantly employed, while non-contact optical measurement techniques remain underrepresented. Astigmatic displacement microscopy (ADM) represents an innovative technique based on astigmatism measurement, offering distinct advantages including non-contact operation, extensive scanning range, rapid imaging speed, and axial nanometer-scale resolution. To incorporate this advanced technology into the “101 Plan” chemical metrology experiments, we have independently developed a customized ADM instrument specifically designed for instructional purposes and established a comprehensive experimental teaching protocol. This experiment integrates interdisciplinary knowledge from chemistry, optics, electronics, and micro-nano characterization. Through four modular components—displacement signal calibration, three-dimensional imaging, vibration analysis, and film thickness measurement—the curriculum aims to stimulate students’ critical thinking regarding cutting-edge developments in micro-nano characterization, enhance their understanding of the significance of high-precision characterization technologies in advanced manufacturing, and foster confidence in domestic instrument innovation through hands-on practice, thereby cultivating specialized talent in instrumentation.
- Chemical metrology experiments,
- Astigmatic displacement microscopy,
- Micro-nano characterization,
- Teaching instrument,
- Instrument development
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