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Citation: Jing Zeng, Yue Zhang, Yuanrui Chen, Xiaobo Yang, Zhen Zhao. Teaching strategies for synthetic route design of target organic molecules in university organic chemistry courses[J]. University Chemistry, ;2026, 41(7): 406-414. doi: 10.12461/PKU.DXHX202506077 shu

Teaching strategies for synthetic route design of target organic molecules in university organic chemistry courses

Jing Zeng ¹ ,
Yue Zhang ¹ ,
Yuanrui Chen ² ,
Xiaobo Yang ^1,, ,
Zhen Zhao ^1,,

1.
College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, Liaoning Province, China;
2.
College of Teacher Education, Shenyang Normal University, Shenyang 110034, Liaoning Province, China

Corresponding author: Xiaobo Yang, Zhen Zhao,
Received Date: 18 June 2025
Revised Date: 4 September 2025

In university-level organic chemistry instruction, particularly at mid-tier institutions, students frequently demonstrate deficiencies in designing synthetic routes for organic molecules. Drawing upon classical retrosynthetic analysis methodology and extensive teaching experience, this study presents four pedagogical strategies: identification of characteristic structural features in target molecules, analysis of structural disparities between target molecules and starting materials, mastery of key reaction product characteristics, and cultivation of divergent thinking approaches. These strategies aim to enhance students’ synthetic route design capabilities and knowledge integration skills while stimulating learning engagement, thereby optimizing instructional outcomes in organic chemistry education.
- Organic chemistry,
- Teaching strategy,
- Synthetic route,
- Molecular structure features,
- Structural differences
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