Citation: Fen Tan, Cong Xiong, Yu-Xuan Ni, Zhihan Zhang, Ke Gao, Wen-Jing Xiao, Liang-Qiu Lu. Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”[J]. University Chemistry, ;2026, 41(6): 53-59. doi: 10.12461/PKU.DXHX202506066 shu

Carbene chemistry teaching integrated with cutting-edge single-atom skeletal editing of indoles: a case study in organic chemistry education under the “101 Plan”

Fen Tan ^1,2 ,
Cong Xiong ¹ ,
Yu-Xuan Ni ¹ ,
Zhihan Zhang ¹ ,
Ke Gao ¹ ,
Wen-Jing Xiao ¹ ,
Liang-Qiu Lu ^1,,

1.
College of Chemistry, Central China Normal University, Wuhan 430079, Hubei Province, China;
2.
School of Chemistry and Life Sciences, Hubei University of Education, Wuhan 430205, Hubei Province, China

Corresponding author: Liang-Qiu Lu, luliangqiu@ccnu.edu.cn
Received Date: 15 June 2025
Revised Date: 29 August 2025

Aligned with the talent development objectives of the Chemistry “101 Plan”, this study employs carbene intermediates as a conceptual bridge to incorporate advanced single-atom skeletal editing research into organic chemistry pedagogy. Through a three-phase instructional model encompassing “theoretical fundamentals, literature analysis, and innovative design”, students are guided to apply foundational carbene chemistry principles to examine the mechanisms of single-atom skeletal editing in indole molecules. This teaching paradigm demonstrates a replicable approach for integrating core knowledge with frontier research, contributing to the ongoing reform of organic chemistry curricula.
- Chemistry “101 Plan”,
- Curriculum reform,
- Organic chemistry,
- Carbene,
- Indole,
- Single-atom skeletal editing
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