Citation: Yi Huang, Yansong Xiao, Xingxing Ma, Qiuling Song. Zweifel olefination: an innovative approach to highly efficient stereoselective alkene synthesis[J]. University Chemistry, ;2026, 41(7): 119-125. doi: 10.12461/PKU.DXHX202506046 shu

Zweifel olefination: an innovative approach to highly efficient stereoselective alkene synthesis

College of Chemistry, Fuzhou University, Fuzhou 350108, Fujian Province, China

Corresponding author: Xingxing Ma, Qiuling Song,
Received Date: 10 June 2025
Revised Date: 2 September 2025

The Zweifel olefination serves as an effective methodology for constructing C=C double bonds, distinguished by its high efficiency, exceptional stereoselectivity, and transition-metal-free catalytic system. This review comprehensively examines the reaction mechanism, pathway, and recent advancements in this field. Through a systematic discussion of this novel stereoselective alkene synthesis strategy, we intend to enhance undergraduate chemistry students’ understanding of stereochemical principles while expanding their repertoire for obtaining alkenes with defined configurations. This perspective ultimately contributes to the enrichment of their organic synthesis knowledge framework.
- Zweifel reaction,
- C=C double bond,
- High stereoselectivity,
- Transition-metal-free catalyst
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