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Citation: Huiru Sheng, Rui Qi, Chao Shen, Hao Xu, Jiabin Shen, Pengfei Zhang. Green synthesis of pyrrolo[1,2-a]quinoxaline derivatives as antineoplastic agents: a comprehensive chemistry laboratory teaching exploration[J]. University Chemistry, ;2026, 41(7): 266-273. doi: 10.12461/PKU.DXHX202505015 shu

Green synthesis of pyrrolo[1,2-a]quinoxaline derivatives as antineoplastic agents: a comprehensive chemistry laboratory teaching exploration

Huiru Sheng ¹ ,
Rui Qi ¹ ,
Chao Shen ¹ ,
Hao Xu ¹ ,
Jiabin Shen ^1,, ,
Pengfei Zhang ^2,,

1.
Basic Chemistry and Biology Experiments Teaching Center of Zhejiang Province, College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, Zhejiang Province, China;
2.
Experimental Chemistry Teaching Center of Zhejiang Province, College of Materials, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, Zhejiang Province, China

Corresponding author: Jiabin Shen, Pengfei Zhang,
Received Date: 8 May 2025
Revised Date: 29 July 2025

This study focuses on the molecular framework of pyrrolo[1,2-a]quinoxaline, known for its antitumor activity. Utilizing nitric acid and hydrochloric acid as chlorine gas precursors, we achieved a one-step synthesis of pyrrolo[1,2-a]quinoxaline antitumor agents through visible-light-catalyzed ring-opening and ring-closing reactions of arylcyclopropanes. By integrating fundamental organic chemistry principles with cutting-edge research topics, this experiment effectively enhances students’ comprehensive skills and innovative capabilities, making it particularly suitable as an advanced “comprehensive chemistry experiment” course for chemistry majors.
- Ring-opening reaction,
- Ring-closing reaction,
- Pyrrolo[1,2-a]quinoxaline,
- Photocatalysis,
- Homogeneous catalysis
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