Citation: Chunyan Hu, Wei Wang, Zewei Mao, Mei Zhang, Lei Zhang, Yuping Lin. Three-stage progressive teaching reform and practice in organic chemistry experiments for pharmacy undergraduates: synthesis of coumarin-chalcone derivatives[J]. University Chemistry, ;2026, 41(7): 282-289. doi: 10.12461/PKU.DXHX202505011 shu

Three-stage progressive teaching reform and practice in organic chemistry experiments for pharmacy undergraduates: synthesis of coumarin-chalcone derivatives

School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan Province, China

Corresponding author: Yuping Lin, linyuping1221@163.com
Received Date: 8 May 2025
Revised Date: 31 July 2025

Addressing the demands of New Medical Education for cultivating innovative pharmaceutical talents, this study tackles the shortcomings of conventional organic chemistry experiments in pharmacy programs—where verification-based exercises dominate, leading to passive student participation without comprehensive understanding of experimental design, reaction mechanisms, or drug development logic. We established a three-stage progressive project-based teaching system comprising “theoretical foundation - innovative design - comprehensive practice”, using the innovative synthesis of coumarin-chalcone derivatives as a model drug scaffold. This framework synergizes theoretical instruction with experimental investigation, promotes creative synthesis strategy development, and implements interdisciplinary structural characterization training. The approach systematically nurtures students’ scientific thinking from molecular design to structural elucidation while strengthening core pharmaceutical competencies, offering an implementable model for experimental pedagogy reform in pharmaceutical education under the New Medical Education framework.
- Pharmacy undergraduate,
- Organic chemistry experiment,
- Systems thinking,
- Coumarin-chalcone hybrids
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