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Citation: Mingli Gao, Hongyan Feng, Chenxiao Jiang, Zihao Wang, Weisheng Yu. A comprehensive exploratory experiment on esterification reaction in microreactors[J]. University Chemistry, ;2026, 41(7): 250-256. doi: 10.12461/PKU.DXHX202504035 shu

A comprehensive exploratory experiment on esterification reaction in microreactors

1.
National Demonstration Center for Experimental Chemistry Education (University of Science and Technology of China), Hefei 230026, Anhui Province, China;
2.
Department of Applied Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, Anhui Province, China

Corresponding author: Hongyan Feng, fenghy@ustc.edu.cn
Received Date: 8 April 2025
Revised Date: 20 June 2025

This study presents an innovative comprehensive experiment utilizing microreactor technology to investigate the esterification reaction between acetic acid and ethanol. Conducted in student groups, the experiment systematically examines the influence of various reaction parameters—including temperature, reactant molar ratio, residence time, and catalyst concentration—on conversion efficiency. Participants acquire skills in employing proton nuclear magnetic resonance (¹H NMR) spectroscopy to monitor reaction progression and quantify conversion rates. The experimental design not only familiarizes students with advanced microreactor technology but also develops their proficiency in quantitative ¹H NMR analysis, while simultaneously enhancing their analytical thinking capabilities.
- Microreactor,
- Comprehensive exploratory experiment,
- Esterification reaction,
- Nuclear magnetic resonance technology
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
  W. Qu, I. Mudawar, Int. J. Heat Mass Tran. 2003, 46(15), 2755．
7. [7]
8. [8]
9. [9]
1. [1]
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2. [2]
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3. [3]
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7. [7]
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8. [8]
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10. [10]
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11. [11]
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14. [14]
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