Citation: Qihao Tang, Xiaohua Xin, Yunxia Wang, Han Wang. Mechanochemically Promoted Photochemical Reactions in Organic Synthesis[J]. University Chemistry, ;2026, 41(6): 321-327. doi: 10.12461/PKU.DXHX202503131 shu

Mechanochemically Promoted Photochemical Reactions in Organic Synthesis

College of Chemistry and Materials Science, Northwest University, Xi'an 710127, Shaanxi Province, China

Corresponding author: Han Wang, hanwang@nwu.edu.cn
Received Date: 27 March 2025
Revised Date: 16 June 2025

Mechanochemical synthesis is an approach that utilizes mechanical energy input, such as grinding and shearing, to promote synthetic reactions, offering notable advantages in terms of environmental sustainability, high efficiency, and energy savings. In recent years, the synergistic interaction between mechanical force and photochemistry has emerged as a research hotspot. By alternating or synchronizing mechanical grinding with light irradiation, the complementary advantages of both techniques can be effectively harnessed. This review systematically summarizes the principles, apparatus, and recent advances in mechanochemically driven photochemical reactions. These innovative methodologies not only expand the application scope of mechanochemistry but also contribute to the green transformation of fields such as organic synthesis and nanomaterial fabrication. Looking ahead, mechanophotochemistry is expected to play a pivotal role in drug development, energy storage, and sustainable synthesis, while also providing new insights for interdisciplinary research. Moreover, this review can help broaden students’ understanding of various chemical disciplines, deepen their comprehension of fundamental reaction mechanisms, enhance their interest in chemistry, and inspire curiosity for exploring the unknown.
- Mechanochemistry,
- Photochemical Reaction,
- Ball Milling Technology,
- Green Synthesis
1. [1]
  S.L. James, C.J. Adams, C. Bolm, D. Braga, P. Collier, T. Friščić, F. Grepioni, K.D.M. Harris, G. Hyett, W. Jones, et al., Chem. Soc. Rev. 2012, 41, 413.
2. [2]
  J. Do, T. Friščić, ACS Cent. Sci. 2017, 3, 13.
3. [3]
  A.a.L. Michalchuk, E.V. Boldyreva, A.M. Belenguer, F. Emmerling, V.V. Boldyrev, Front. Chem. 2021, 9, 685789.
4. [4]
  T. Friščić, C. Mottillo, H.M. Titi, Angew. Chem. Int. Ed. 2020, 59, 1018.
5. [5]
  V.V. Boldyrev, K. Tkáčová, J. Mater. Synth. Process 2000, 8, 121.
6. [6]
  T. Friščić, A.V. Trask, W. Jones, W.D.S. Motherwell, Angew. Chem. Int. Ed. 2006, 45, 7546.
7. [7]
  N. Shan, F. Toda, W. Jones, Chem. Commun. 2002, 20, 2372.
8. [8]
  T. Friščić, S.L. Childs, S.A.A. Rizvi, W. Jones, CrystEngComm. 2009, 11, 418.
9. [9]
  J.G. Hernández, Chem. Eur. J. 2017, 23, 17157.
10. [10]
  G.A. Bowmaker, Chem. Commun. 2013, 49, 334.
11. [11]
  L. Takacs, Chem. Soc. Rev. 2013, 42, 7649.
12. [12]
  P. Baláž, Mechanochemistry in Nanoscience and Minerals Engineering. Springer-Verlag: Berlin, Heidelberg, 2008.
13. [13]
  A.N. Sokolov, D. Bučar, J. Baltrusaitis, S.X. Gu, L.R. Macgillivray, Angew. Chem. Int. Ed. 2010, 49, 4273.
14. [14]
  J. Stojaković, B.S. Farris, L.R. Macgillivray, Faraday Discuss. 2014, 170, 35.
15. [15]
  E. Elacqua, K.A. Kummer, R.H. Groeneman, E.W. Reinheimer, L.R. Macgillivray, J. Photochem. Photobiol., A 2016, 331, 47.
16. [16]
  J.G. Hernández, Beilstein J. Org. Chem. 2017, 13, 1463.
17. [17]
  D.M. Baier, C. Spula, S. Fanenstich, S. Grätz, L. Borchardt, Angew. Chem. Int. Ed. 2023, 62, e202218719.
18. [18]
  C. Spula, V. Becker, G. Talajić, S. Grätz, K. Užarević, L. Borchardt, ChemSusChem. 2025, 18, e202401022.
19. [19]
  X. Xin, J. Geng, D. Zhang, H.T. Ang, H. Wang, Y. Cheng, Y. Liu, R.W. Toh, J. Wu, H. Wang, Nat. Synth. 2025, 4, 177.
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