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Citation: Weifeng Yu, Junqiao Zhuo. Stereoisomeric Analysis of Adamantane and Hexamethylenetetramine[J]. University Chemistry, ;2026, 41(6): 434-440. doi: 10.12461/PKU.DXHX202503125 shu

Stereoisomeric Analysis of Adamantane and Hexamethylenetetramine

Weifeng Yu ^1,, ,
Junqiao Zhuo ²

1.
Chong Qing Chang Sheng Qiao Secondary School, Chongqing 401336, China;
2.
Chong Qing Academy of Education Science, Chongqing 400015, China

Corresponding author: Weifeng Yu, yuweifeng209@163.com
Received Date: 27 March 2025
Revised Date: 19 June 2025

Through structural investigation of hexamethylenetetramine (C₆H₁₂N₄), we developed a “tetrahedral” model for analyzing adamantane molecular structures using chemical spatial thinking. This study proposes a novel approach for examining stereoisomerism (particularly enantiomerism) in disubstituted adamantane and hexamethylenetetramine derivatives, characterized by three distinct substitution patterns: same-ring same-carbon, same-ring different-carbon, and different-ring different-carbon. Systematic analysis of disubstituted hexamethylenetetramine (C₆H₁₂N₄) and adamantane (C₁₀H₁₆) stereostructures was conducted using this tetrahedral model. Notably, the three-dimensional tetrahedral model can be dimensionally reduced to a two-dimensional planar triangle configuration, thereby establishing an innovative methodology for stereostructural analysis of these disubstituted compounds. This approach may offer new perspectives for investigating analogous stereochemical systems.
- Adamantane,
- Tetrahedral,
- Model,
- Spatial thinking
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