Home

Citation: Siwen Yuan, Qilin Wu, TianpengYin. NMR Spectroscopy Teaching Design Using the Mosher Method for Stereochemistry of Organic Compounds Based on BOPPPS Teaching Model[J]. University Chemistry, ;2025, 40(7): 161-168. doi: 10.12461/PKU.DXHX202502073 shu

NMR Spectroscopy Teaching Design Using the Mosher Method for Stereochemistry of Organic Compounds Based on BOPPPS Teaching Model

School of Bioengineering, Zunyi Medical University, Zhuhai 519041, Guangdong Province, China

Corresponding author: TianpengYin, ytp@zmu.edu.cn
Received Date: 17 February 2025
Revised Date: 7 April 2025

The determination of stereochemistry represents a fundamental aspect in both Organic Chemistry and Medicinal Chemistry, constituting an essential competency for graduate students in related disciplines. While the Mosher method has been extensively employed for stereochemical determination of secondary alcohols and amines in pharmaceutical molecules, dedicated pedagogical reports remain scarce. This paper implemented the BOPPPS teaching model, integrating information technology, to develop and execute a graduate-level curriculum focusing on spectral analysis through authentic research cases. The instructional design aimed to facilitate students' rapid acquisition of the Mosher method's theoretical principles, practical applications, and operational techniques. The results demonstrated that this teaching approach not only enhanced students' comprehension of theoretical knowledge but also significantly improved their problem-solving capabilities in practical contexts, thereby presenting a valuable pedagogical model worthy of broader dissemination and adaptation.
- BOPPPS teaching model,
- Stereochemistry,
- Mosher method,
- Spectral analysis
1. [1]
2. [2]
3. [3]
  Dale, J. A.; Mosher, H. S. J. Am. Chem. Soc. 1973, 95 (2), 512.
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
  Guo, H.; Wu, Q.; Chen, D.; Jiang, M.; Chen, B.; Lu, Y.; Li, J.; Liu, L.; Chen, S. Bioorg. Chem. 2021, 115(34), 105156.
11. [11]
1. [1]
  Jinkang Jin , Yidian Sheng , Ping Lu , Zhan Lu . Introducing a Website for Learning Nuclear Magnetic Resonance (NMR) Spectrum Analysis. University Chemistry, 2024, 39(11): 388-396. doi: 10.12461/PKU.DXHX202403054
2. [2]
  Wenwen Ma , Liyan Liu , Chengyang Yin , Hongdan Zhang , Lian Kong , Na Wei , Zhan Yu , Zhen Zhao . Exploration of the Online and Offline Mixed Teaching Mode of Specialized English for Chemistry Majors Based on the BOPPPS Model. University Chemistry, 2025, 40(9): 287-294. doi: 10.12461/PKU.DXHX202410026
3. [3]
  Huiwen Yao , Ming Yuan , Shunbo Zhang , Yongsheng Gao , Tangbin Liao , Shumin Feng , Li Cao . Practice and Application of the “Online and Offline + BOPPPS” Teaching Model in Organic Chemistry at Traditional Chinese Medicine Institutions. University Chemistry, 2025, 40(11): 127-133. doi: 10.12461/PKU.DXHX202412122
4. [4]
  Geshan Zhang , Haodong Tang , Zongjian Liu , Feng Feng . Application of the BOPPPS Effective Teaching Model in Bilingual Physical Chemistry Instruction: A Case on Colligative Properties of Dilute Solutions. University Chemistry, 2025, 40(11): 376-381. doi: 10.12461/PKU.DXHX202412127
5. [5]
  Jianquan Liu , Xiangshan Wang . Teaching Design and Practice of Naming Rules for Circular Isomer Configuration under the Guidance of Information Literacy. University Chemistry, 2025, 40(7): 352-358. doi: 10.12461/PKU.DXHX202409082
6. [6]
  Chengxia Tong , Yajie Li , Jin Yan , Xuejian Qu , Shigang Wei , Yong Fan , Zhiguang Song , Yupeng Guo . The Construction and Practice of a Comprehensive and Three-Dimensional Practical Education Model. University Chemistry, 2024, 39(7): 49-55. doi: 10.12461/PKU.DXHX202404155
7. [7]
  Haiyang Jin , Yonghai Hui , Yongfei Zhang , Lijun Gao , Yun Wang . Application and Exploration of Nuclear Magnetic Resonance Spectrometer in Undergraduate Basic Laboratory Teaching. University Chemistry, 2025, 40(3): 245-250. doi: 10.12461/PKU.DXHX202406022
8. [8]
  Yiying Yang , Rongxiu Zhu , Yuchen Ma , Dongju Zhang . MATLAB-based Visualization of Hydrogen-Like Orbitals and Analysis of Relavant Teaching Problems. University Chemistry, 2025, 40(9): 375-382. doi: 10.12461/PKU.DXHX202411015
9. [9]
  Zhi Chai , Huashan Huang , Xukai Shi , Yujing Lan , Zhentao Yuan , Hong Yan . Wittig反应的立体选择性. University Chemistry, 2025, 40(8): 192-201. doi: 10.12461/PKU.DXHX202410046
10. [10]
  Zhenlin Zhou , Siyuan Chen , Yi Liu , Chengguo Hu , Faqiong Zhao . A New Program of Voltammetry Experiment Teaching Based on Laser-Scribed Graphene Electrode. University Chemistry, 2024, 39(2): 358-370. doi: 10.3866/PKU.DXHX202308049
11. [11]
  Wei Peng , Baoying Wen , Huamin Li , Yiru Wang , Jianfeng Li . Exploration and Practice on Raman Scattering Spectroscopy Experimental Teaching. University Chemistry, 2024, 39(8): 230-240. doi: 10.3866/PKU.DXHX202312062
12. [12]
  Liqiang Huang , Peng Lin . 数-图分析法解释仪器分析实验课程教学中的难点. University Chemistry, 2025, 40(6): 353-359. doi: 10.12461/PKU.DXHX202407074
13. [13]
  Fengmei Wang , Xin Zhang , Hong Yan , Xiangyu Xu , Guirong Wang . Inverted 'Π' Graphic Memory Method for Thermodynamic Basic Equations and the Application in Teaching Practice. University Chemistry, 2025, 40(11): 369-375. doi: 10.12461/PKU.DXHX202412087
14. [14]
  Yuqiao Zhou , Weidi Cao , Shunxi Dong , Lili Lin , Xiaohua Liu . Study on the Teaching Reformation of Practical X-ray Crystallography. University Chemistry, 2024, 39(3): 23-28. doi: 10.3866/PKU.DXHX202303003
15. [15]
  Wen Zhou , Hui Zhou , Chen Xie , Quli Fan . Exploration of a Dual-Line P-BOPPPS-E Teaching Approach Guided by Curriculum-Based Ideological and Political Education in Physical Chemistry. University Chemistry, 2025, 40(11): 92-99. doi: 10.12461/PKU.DXHX202412056
16. [16]
  Xinxue Li . The Application of Reverse Thinking in Teaching of Boiling Point Elevation and Freezing Point Depression of Dilute Solutions in General Chemistry. University Chemistry, 2024, 39(11): 359-364. doi: 10.3866/PKU.DXHX202401075
17. [17]
  Lihua Jin , Lei Tian , Chaozhan Wang , Jiawei Liu , Quan Bai , Yan Li . Teaching Exploration and Practice of the Instrumental Analysis Experiment “Distinguishing Green Plastic Bags by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy”. University Chemistry, 2026, 41(2): 360-365. doi: 10.12461/PKU.DXHX202502089
18. [18]
  Xinyue Zhao , Min Wang . Teaching Differentiation of t-Test for Grouped Data in Analytical Chemistry: A Case Study of Chloride Concentration in Surface vs. Bottom Lake Water. University Chemistry, 2026, 41(3): 227-232. doi: 10.12461/PKU.DXHX202511022
19. [19]
  Xu Liu , Chengfang Liu , Jie Huang , Xiangchun Li , Wenyong Lai . Research on the Application of Diversified Teaching Models in the Teaching of Physical Chemistry. University Chemistry, 2024, 39(8): 112-118. doi: 10.3866/PKU.DXHX202402021
20. [20]
  Ruiying WANG , Hui WANG , Fenglan CHAI , Zhinan ZUO , Benlai WU . Three-dimensional homochiral Eu(Ⅲ) coordination polymer and its amino acid configuration recognition. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 877-884. doi: 10.11862/CJIC.20250052

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(676)
HTML views(44)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return