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Citation: Meihui Cai, Yi Huang, Xingxing Ma, Qiuling Song. Exploring the Mysteries of the Petasis-Boronic Acid-Mannich Reaction[J]. University Chemistry, ;2025, 40(11): 184-190. doi: 10.12461/PKU.DXHX202412054 shu

Exploring the Mysteries of the Petasis-Boronic Acid-Mannich Reaction

College of Chemistry, Fuzhou University, Fuzhou 350108, China

Corresponding author: Xingxing Ma, Qiuling Song,
Received Date: 11 December 2024
Revised Date: 15 April 2025

This review provides a comprehensive examination of the Petasis-boronic acid-Mannich reaction, systematically elucidating its origin, reaction mechanism, research progress, and applications in organic synthesis. As a significant advancement in organoboron chemistry, this reaction represents an innovative extension of the traditional Mannich reaction and contributes to the enrichment of university-level organic chemistry curricula. By introducing the Petasis-boronic acid-Mannich reaction, this work aims to enhance students’ understanding of advanced organic reactions while fostering their interest and enthusiasm for exploring the field of organoboron chemistry, building upon their foundational knowledge of the classical Mannich reaction.
- Petasis reaction,
- Organoboronic acid,
- Multicomponent reaction,
- Allylamine,
- Benzylamine
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