Citation: ZHAI Qing-Feng, LI Jing, WANG Er-Kang. Application of Single Solid State Nanopore/Nanochannel Based on Polymer Membrane and Glass Nanopipette in Analytical Chemistry[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(6): 814-825. doi: 10.11895/j.issn.0253-3820.181256 shu

Application of Single Solid State Nanopore/Nanochannel Based on Polymer Membrane and Glass Nanopipette in Analytical Chemistry

1.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 18 April 2018
Revised Date: 14 May 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21427811), the Youth Innovation Promotion Association CAS (No. 2016208) and MOST China (Nos. 2016YFA0203200, 2016YFA0201300) and Jilin Province Science and Technology Development Plan Project (No. 20170101194JC).

Nanopore/nanochannel sensing technique drawing more attention in analytical chemistry due to its unique advantages and the fabricated electrochemical sensors and electrochemical responsive gates have been widely used for more target detection, including single molecule protein and DNA sequencing. Nanopore/nanochannel that used for fabricating electrochemical detection system is mainly divided into biological nanopore and solid state nanopore, and among them, solid state nanopore/nanochannel has a wide range of application due to its inherent properties, such as easy for modification, good mechanical property and stability. Resistive pulse sensing and current-voltage curves (ion current rectification) are two main methods of nanopore/nanochannel sensing technique used for target analysis, so in this review, we introduced the fundamentals and applications of nanopore sensing technique based on the above two methods. In addition, we concluded the application and development of single state nanopore/nanochannel in recent years, and also gave a brief look at the future challenges and prospects in the development of this field.
- Single solid nanopore/nanochannel,
- Resistive pulse,
- Ion current rectification,
- Sensor,
- Responsive gate,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142