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Citation: LIU Jia-Rong, HUANG Zhong-Ping, LIU Hui-Jun, WANG Li-Li, LIU Chun-Sheng, REN Yi-Ping, SHI Hong-Xin. Rapid Determination of γ-Hydroxybutyric Acid in Beverage and Urine by Direct Analysis in Real-time Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(5): 698-703. doi: 10.11895/j.issn.0253-3820.171375 shu

Rapid Determination of γ-Hydroxybutyric Acid in Beverage and Urine by Direct Analysis in Real-time Mass Spectrometry

¹ College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;
² ASPEC Technologies Limited, Beijing 100101, China;
³ National Center for Food Safety Risk Assessment Application Technology Cooperation Center, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China

Received Date: 27 October 2017
Revised Date: 5 February 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 51503182), the Analysis and Measurement Foundation of Zhejiang Province (No.2017C37064) and Key Laboratory Item of Furniture Inspection Technology of Zhejiang Province, China (No.2016J01).

A method for rapid determination of γ-hydroxybutyric acid (GHB) in beverages (water, sodas, beer) and urine was established by direct analysis real-time mass spectrometry (DART-MS). Samples were analyzed directly after dilution with mixture of methanol and water (1:1, V/V). Instrument parameter settings were optimized to obtain the sensitive and accurate determination of GHB. At the sample introduction speed of 0.5 mm/s, high intensity of[M-H]^- ions for GHB were observed in the negative ion and selection ion monitoring mode by utilization of high purity helium gas at 350℃. For different samples of water, sodas, beer and urine, the limits of detection (LODs) (S/N=3) were in the range of 1-2 μg/mL, while the limits of quantification (LOQs) (S/N=10) were in the range of 3-5 μg/mL. The linear correlation coefficients of the standard curves with different sample matrixes were between 0.9899 and 0.9980. The recoveries were in the range of 80.8%-115.2% with the relative standard deviations of 1.9%-12.8%. With its rapid analysis and simple pretreatment steps, the method is expected to have a strong advantage in the rapid screening analysis of large quantities of beverage and urine.
- Direct analysis in real-time mass spectrometry,
- γ-Hydroxybutyric acid,
- Rapid screening
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