Citation: JIANG Xiang-Yu, FU Hua, Zhang Min, FU Zhi-Bo, WANG Yue-Rong, ZHANG Hong-Yang, HU Ping. Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(7): 1077-1083. doi: 10.11895/j.issn.0253-3820.171347 shu

Molybdenum Disulfide Quantum Dots-based Fluorescence Sensor for Detection of Doxycycline Hyclate

1.
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East-China University of Science and Technology, Shanghai 200237, China;
2.
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

Received Date: 17 October 2017
Revised Date: 8 April 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No.81573397) and the Shanghai Natural Science Foundation (No.15ZR1409400).

Molybdenum disulfide (MoS₂) quantum dots (QDs) were synthesized using one-step hydrothermal method with an acceptable fluorescence property. Based on the quenching effect between doxycycline hyclate (DOX) and MoS₂ QDs, a fluorescence method for detection of DOX was established. The interaction between MoS₂ QDs and DOX was discussed with a final proposal of the static quenching mechanism. A good linear correlation for detection of DOX using fluorescenct MoS₂ QDs was obtained in the concentration range of 0.86-55.40 μg/mL, with a detection limit of 0.023 μg/mL (S/N=3). The fabricated sensor was applied to the detection of DOX in real samples with RSDs of less than 5%. The relative error of determination results of MoS₂ QDs method compared with HPLC was from -4.5% to 0.8% and -4.6% to 2.8% for DOX tablet and DOX spiked milk, respectively. The fluorescence detection of DOX in real sample using MoS₂ QDs was simple, rapid and reliable.
- Molybdenum disulfide,
- Quantum dot,
- Fluorescence sensor,
- Doxycycline hyclate
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1.
沈阳化工大学材料科学与工程学院沈阳 110142