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Citation: LAN Meng-Fei, AN Ning, ZHAO Ying, CAO Wei, LI Heng, ZHAO Lan, HUANG Yong-Dong, ZHANG Rong-Yue. Effect of Porogen Solubility Parameter on Structure of Chromatographic Supports with Large Pores[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(2): 288-292. doi: 10.11895/j.issn.0253-3820.171299 shu

Effect of Porogen Solubility Parameter on Structure of Chromatographic Supports with Large Pores

LAN Meng-Fei ^1, ,
AN Ning ¹ ,
ZHAO Ying ¹ ,
CAO Wei ¹ ,
LI Heng ¹ ,
ZHAO Lan ² ,
HUANG Yong-Dong ² ,
ZHANG Rong-Yue ¹

1.
Beijing Key Laboratory of Fuels Cleaning and Advanced Catalytic Emission Reduction Technology/College of Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, China;
2.
National Key Lab of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

Received Date: 7 October 2017
Revised Date: 21 November 2017

Fund Project: This work was supported by Beijing Natural Science Foundation, China (No. 2162013).

The macroporous microspheres were prepared through suspension polymerization and based on a copolymer of glycidyl methacrylate and ethylene glycol dimethacrylate. The effect of porogen on the microspheres structure was evaluated in terms of pore size and surface area. Porogen contained dichloromethane (δ=9.7 (cal/cm³)^1/2) and N-octanol (δ=10.3 (cal/cm³)^1/2) which corresponded to a good and poor solvent, respectively. The solubility parameter of porogen was controlled in the range of 9.89-10.09 (cal/cm³)^1/2. The pore size of microspheres increased with the difference value of solubility parameter between the polymer and the porogen. On the contrary, the surface area of microspheres decreased in this study. The anion exchange media was prepared through coupling poly(ethylene imine) in the microspheres, and the proteins transport was determined by frontal analysis method. The macroporous microspheres with 257 nm pore size could still afford a high proteins capacity (45.1 mg/mL). These macroporous supports showed a large potential in a rapid separation of proteins.
- Porogen,
- Solubility parameter,
- Macroporous microspheres,
- Protein,
- Separation
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