Citation: BAI Xue-Jie, YU Wen-Jing, WANG Yi-Han, SHI Lei, SU Rui, XU Rui-Feng, CHEN Da-Zhou, YANG Hong-Mei, LIU Shu-Ying. Rapid Identification of Oligosaccharide Isomers by Electron Capture Dissociation in Combination with Metal Ions[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(1): 55-60. doi: 10.11895/j.issn.0253-3820.171261 shu

Rapid Identification of Oligosaccharide Isomers by Electron Capture Dissociation in Combination with Metal Ions

BAI Xue-Jie ^1, ,
YU Wen-Jing ² ,
WANG Yi-Han ² ,
SHI Lei ³ ,
SU Rui ² ,
XU Rui-Feng ⁴ ,
CHEN Da-Zhou ⁴ ,
YANG Hong-Mei ^2,3 ,
LIU Shu-Ying ²

1.
School of Pharmacy, Changchun Medical College, Changchun 130031, China;2 Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China;3 School of Nuclear Technology and Chemical Biology, Hubei University of Science and Technology, Xianning 437100, China;4 Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing 100013, China

Received Date: 20 September 2017
Revised Date: 6 October 2017

Fund Project: This work was supported by the Science and Technology Development Planning Project of Jilin Province, China (Nos. 20170623026TC, 20160101220JC, 20160204027YY) and the Health Technology Innovation Project of Jilin Province, China (No.2016J098).

Oligosaccharide isomers were distinguished by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD-FT-ICR-MS) in combination with utilizing alkali, alkaline earth, and transition metals (Na⁺, Ca²⁺, Ba²⁺,Mg²⁺, Mn²⁺ and Co²⁺) as charge carriers in electrospray. Maltoheptaose, mannohexaose and laminarihexaose were taken as examples to investigate influence of metal ions on the extent of oligosaccharide fragmentation. The same types of fragmentation ions (^0,2A and ^2,4A) were obtained for barium-and calcium-adducted maltoheptaose. Mg²⁺ and Mn²⁺ had the similar influence (^0,2A, ^2,4A and ^2,5A). Three cross-ring cleavage ions (^1,4A, ^2,4A and ^2,5A) were generated in the spectrum of cobalt-associated maltoheptaose. But in the case of doping Na⁺ into maltoheptaose, only ^0,2A ion was detected. It was found that the signals in the spectra of mannohexaose and laminarihexaose were worse than that in the spectrum of maltoheptaose, probably resulting from different numbers of adducted metal ions. The isomers, mannohexaose and laminarihexaose could be distinguished by ECD-MS in conjunction with the addition of Ca²⁺, Mg²⁺ or Co²⁺. The addition of Ca²⁺ was the best choice for analysis of oligosaccharides.
- Fourier transform-ion cyclotron resonance-mass spectrometry,
- Electron capture dissociation,
- Metal ion,
- Oligosaccharide isomer
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