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Citation: LIU Hong-Wen, JI Ying, SONG Chun-Li, TIAN Gang, LI Shi-Ya, YANG Gui-Ying, LYU Chang-Yin. Pb²⁺-Induced Allosteric PS2.M as A Label-Free Colorimetric Sensor for Detection of Cumulative Radon Radiation[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(5): 658-663. doi: 10.11895/j.issn.0253-3820.171151 shu

Pb²⁺-Induced Allosteric PS2.M as A Label-Free Colorimetric Sensor for Detection of Cumulative Radon Radiation

School of Public Health, University of South China, Hengyang 421000, China

Received Date: 5 August 2017
Revised Date: 31 March 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 81473021) and Graduate Student Research Innovation Project in Hunan Province, China (No. CX2017B557).

A new sensitive method for detection of cumulative radon radiation based on the lead was established. PS2.M which stabilized by K⁺ with hemin as a co-factor exhibits superior peroxidase-like activity, and can effectively catalyze the H₂O₂-mediated oxidation of TMB. In the presence of Pb²⁺, K⁺-stabilized PS2.M DNAzymes are induced to undergo a conformational change, because Pb²⁺ has a higher efficiency with regard to stabilizing G-quadruplexes than K⁺, accompanied by a decrease of catalytic activity and a sharp decrease of readout signal. In the work, a novel "turn-off" model of colorimetry-Pb²⁺ biosensor based on superior peroxidase-like activity of G-quadruplex for Pb²⁺ analysis was developed. The fading degree of reaction system (ΔA value) was linearly related to Pb²⁺ concentration in the range of 5.0×10^-9-1.8×10^-7 mol/L. The linear regression equation was ΔA=0.36+0.13C (10^-8 mol/L), with R=0.9987. The detection limits of lead and radon were 3.76 nmol/L(S/N=3) and 1.96×10³ Bq·h/m³(S/N=3), respectively. The method exhibited good selectivity, high sensitivity and convenient operation, and could avoid the radioactive hazard in determination of the radon in environment.
- Radon,
- Lead,
- Aptamer,
- G-quadruplex,
- Conformation transformation,
- Colorimetric sensor
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Pb2+-Induced Allosteric PS2.M as A Label-Free Colorimetric Sensor for Detection of Cumulative Radon Radiation

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通讯作者: 陈斌, bchen63@163.com

Pb²⁺-Induced Allosteric PS2.M as A Label-Free Colorimetric Sensor for Detection of Cumulative Radon Radiation