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Citation: ZENG Nian-Yin, ZHU Pan-Pan, LI Yu-Rong, JIANG Hai-Yan, DU Min. Study on Mathematical Model and Simulation of Competition-type Lateral Flow Immunoassay[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(9): 1284-1290. doi: 10.11895/j.issn.0253-3820.170281 shu

Study on Mathematical Model and Simulation of Competition-type Lateral Flow Immunoassay

1.
Department of Instrumental and Electrical Engineering, Xiamen University, Xiamen 361005, China;2 Fujian Key Laboratory of Medical Instrumentation and Pharmaceutical Technology, Fuzhou University, Fuzhou 350116, China

Received Date: 4 May 2017
Revised Date: 21 July 2017

Fund Project: This work was supported by the UK-China Industry Academia Partnership Programme (No.UK-CIAPP/276), the National Natural Science Foundation of China (No. 61403319), the Natural Science Foundation of Fujian Province, China (No. 2015J05131) and the Fujian Provincial Key Laboratory of Eco-Industrial Green Technology.

A mathematical model of competition-type lateral flow immunoassay (LFIA) was developed to describe the dynamic process of LFIA. The competition-type LFIA was divided into two categories:TwA-competition-type LFIA and TnA-competition-type LFIA. On the basis of the developed model, the COMSOL software was exploited to simulate the dynamic process of LFIA. The simulation result demonstrated the relationships between the concentrations of substances on the test and control lines and the influence factors. In particular, the influence factors in the TwA-competition-type LFIA included the concentrations of target analyte A (0-20 mol/L) and reporter particle P (0.01-100 mol/L), and the position of the test line (5-20 mm). On the other hand, the influence factors in the TnA-competition-type LFIA included the concentrations of target analyte A (0-20 mol/L) and reporter particle P (0.01-100 mol/L), and the porosity. Experiment result showed that the developed model could be used to explore the influence of the parameters on the test results, and optimize the performance of LFIA.
- Lateral flow immunoassay,
- Competition-type,
- Convection-diffusion equation,
- Mathematical model,
- Biochemical reaction process
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