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Citation: BAI Hui-Ping, WANG Chun-Qiong, CAO Qiu-E. Molecularly Imprinted Electrochemical Sensor for Determination of Cholesterol Based on Signal Amplification of Graphene[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(10): 1535-1541. doi: 10.11895/j.issn.0253-3820.170215 shu

Molecularly Imprinted Electrochemical Sensor for Determination of Cholesterol Based on Signal Amplification of Graphene

1.
School of Chemical Science and Technology, Yunnan University, Kunming 650091, China;2 School of Material Science and Technology, Yunnan Key Laboratory of Micro/Nano Materials & Technology, Yunnan University, Kunming 650091, China;3 Yunnan Tobacco Quality Supervision and Test Station, Kunming 650106, China

Received Date: 5 April 2017
Revised Date: 7 August 2017

Fund Project: This work was supported by the Research Foundation of Yunnan Provincial Education Department (No. 2017ZZX231) and the National Natural Science Foundation of China (Nos. 21465025, 21505119).

An electrochemical sensor was fabricated for determination of cholesterol (ChO) based on the molecularly imprinting and signal amplification of graphene. The sensor was prepared by electropolymerizing phenol on the surface of graphene modified glassy carbon electrode with ChO as template. The structure, properties and molecular imprinting effect of the imprinted membrane were studied by SEM, CV and DPV. The results showed that the sensor had good selectivity and high sensitivity to cholesterol. The calibration graph for the determination of cholesterol was linear in the range of 8.0×10^-8-2.0×10^-4 mol/L, with the detection limit (S/N=3) of 5.6×10^-8 mol/L. The sensor was applied to the determination of cholesterol in human serum samples with satisfactory results.
- Graphene,
- Cholesterol,
- Molecularly imprinted membrane,
- Electrochemical sensor
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