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Citation: YANG Meng-Rui, LI Peng, WANG Min, ZHOU Jian, LIU Fang, ZHANG Li-Yuan. Analysis of Small Molecules by Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry with Porous Zeolite Supported α-Cyano-4-Hydroxycinnamic Acid as Composite Matrix[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(10): 1542-1546. doi: 10.11895/j.issn.0253-3820.170209 shu

Analysis of Small Molecules by Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry with Porous Zeolite Supported α-Cyano-4-Hydroxycinnamic Acid as Composite Matrix

Institute of Quality Standard and Testing Technology for Agro-Products, Key Laboratory of Agro-Product Quality and Safety, Chinese Academy of Agriculture, Beijing 100081, China

Received Date: 31 March 2017
Revised Date: 5 July 2017

Fund Project: This work was supported by the Central Public-interest Scientific Institution Basal Research Fund in China (No. 1610072016010)

Zeolite supported α-cyano-4-hydroxycinnamic acid (CHCA) as novel composite matrix was applied in matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis of substance P and small molecular compounds of fluoroquinolones. In the experiment, this new matrix was examined and compared with conventional organic matrix CHCA. The results indicated that the novel composite matrix was capable of suppressing the alkali metal related peaks and interference fragments, simplifying mass spectra in low-molecular-weight region, and promoting ionization efficiency. The influence of SiO₂/Al₂O₃ ratio of ZSM-5 and porous diameter of ZSM-5 and Beta zeolites on performance of MALDI-TOF-MS analysis of substance P was also investigated under the same conditions. In contrast, it was regarded that the strong surface acidity and sufficient cavity for loading CHCA were beneficial for interference fragments suppression and peak intensity enhancement. Additionally, it was successfully applied in the detection of enrofloxacin and ciprofloxacin in complex samples.
- Porous zeolite,
- Matrix assisted laser desorption ionization time-of-flight mass spectrometry,
- Small compounds,
- Fluoroquinolones
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