Citation: YANG Li-Li, SONG Yi-Lin, XU Sheng-Wei, ZHANG Yu, XIAO Gui-Hua, ZHANG Song, GAO Fei, LI Zi-Yue, CAI Xin-Xia. Monitoring of Subthalamic Nucleus Stimulation-induced Dopamine Flux and Spike Firing Change of Striatum Neurons with a Micro-Nano Electrode Array[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(7): 1088-1095. doi: 10.11895/j.issn.0253-3820.170116 shu

Monitoring of Subthalamic Nucleus Stimulation-induced Dopamine Flux and Spike Firing Change of Striatum Neurons with a Micro-Nano Electrode Array

YANG Li-Li ^1,2, ,
SONG Yi-Lin ^1,2 ,
XU Sheng-Wei ^1,2 ,
ZHANG Yu ^1,2 ,
XIAO Gui-Hua ^1,2 ,
ZHANG Song ^1,2 ,
GAO Fei ^1,2 ,
LI Zi-Yue ^1,2 ,
CAI Xin-Xia ^1,2

1.
State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China;
2.
University of Chinese Academy of Sciences, Beijing 100190, China

Received Date: 27 February 2017
Revised Date: 24 April 2017

Fund Project: This work was supported by the National Major Scientific Instruments and Equipments Special Project (No. 61527815) and the National Natural Science Foundation of China (Nos. 61501426, 61601435, 31500800) and Beijing Science and Technology Plan (No. Z141100000214002)

Subthalamic nucleus (STN) deep brain stimulation (DBS) has become an important surgical treatment of Parkinson disease, but its exact mechanism is still unclear. In this study, a 16-channel implantable microelectrode array (MEA) was prepared by micro-electromechanical system (MEMS) technique and later modified with platinum black/reduced Graphene Oxide/Nafion (Pt/RGO/Nafion) nanocomposites. Extracellular dopamine (DA) content and spike of dorsal striatum neurons were synchronously recorded before and after STN stimulation. The results showed that the dopamine content began to increase within 20 s after electrical stimulation and dropped to normal level after about 50 s, with the highest rising concentration of 1.72 μmol/L. At the same time, there was an increased spike activity of interneurons in the dopamine ascending phase, and the spike firing rate of medium spiny projection neurons (MSNs) was high when the concentration of DA was higher than the normal level. The MEA sensor can simultaneously record dopamine flux and physiological signals in situ, thus providing an ideal tool for neural information detection.
- Micro-electromechanical systems,
- Micro-nano electrode array,
- Subthalamic nucleus stimulation,
- Dopamine,
- Spike
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