Citation: SANG Fu-Ming, LI Xin, LIU Jia. Development of Nano-Polymerase Chain Reaction and Its Application[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(11): 1745-1753. doi: 10.11895/j.issn.0253-3820.170097 shu

Development of Nano-Polymerase Chain Reaction and Its Application

School of Marine Science and Technology, Harbin Institute of Technology(Weihai), Weihai 264209, China

Received Date: 17 February 2017
Revised Date: 4 September 2017

Fund Project: This works was supported by the National Natural Science Foundation of China (No. 21407035)

Polymerase chain reaction (PCR) has become one of the powerful technique since its invention in 1980s. Nevertheless, PCR technique is still frequently impaired by its low specificity, poor sensitivity, false positive results, etc. Recently, nanomaterials including metal nanoparticles, carbon nanomaterials, quantum dots and nano metal oxide have been added into PCR solution to improve both quality and productivity of PCR. The nanoparticles assisted PCR (NanoPCR) has received considerable attentions due to its unprecedented sensitivity, selectivity and efficiency. In this view, the mainly used nanoparticles in NanoPCR, including gold nanoparticles, quantum dots, carbon nanomaterials, graphene and metallic oxide, was firstly summarized. And then, the possible mechanisms for highly improved sensitivity and selectivity were discussed. Finally, recent applications of NanoPCR were described.
- NanoPCR,
- Nanomaterials,
- Specificity,
- Amplification efficiency,
- Hot-start,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142