Citation: YUAN Jing-Ze, LU Qi-Peng, WANG Jing-Li, DING Hai-Quan, GAO Hong-Zhi, WU Chun-Yang, LI Wan-Xia. Support Vector Regression for Non-invasive Detection of Human Hemoglobin[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(9): 1291-1296. doi: 10.11895/j.issn.0253-3820.170090 shu

Support Vector Regression for Non-invasive Detection of Human Hemoglobin

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State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics, and Physics, Chinese Academy of Sciences, Changchun 130033, China;2 University of Chinese Academy of Sciences, Beijing 100049, China;3 Cancer Center, The First Hospital of Jinlin University, Changchun 130021, China

Received Date: 16 February 2017
Revised Date: 10 August 2017

Fund Project: This work was supported by the National High Technology Research and Development Program of China (No.2012AA022602) and the National Natural Science Foundation of China (Nos. 61308067, 61475155).

To facilitate noninvasive diagnosis of anemia, high-performance and portable near infrared (NIR) spectrometer for human blood constituents was designed and fabricated based on linear variable filter (LVF). Meanwhile, the performance of support vector regression (SVR) model for quantitative analysis of human hemoglobin (Hb) was investigated. Spectral data were collected noninvasively from 100 volunteers by self-designed LVF-NIR spectrometer, then divided into calibration set, validation set 1 and 2. To establish a robust SVR model, grid search method was applied to optimize the penalty parameter and kernel function parameter c=5.28, g=0.33. Then, Hb levels in the validation 1 and 2 sets were quantitatively analyzed. The results showed that the root mean square error of prediction (RMSEP) were 10.20 g/L and 10.85 g/L, respectively, and the relative RMSEP (R-RMSEP) were 6.85% and 7.48%, respectively. The results indicated that the SVR model had high prediction accuracy to Hb level and adaptability to different samples, and could satisfy the requirements of clinical measurement. Based on the SVR algorithm, the self-designed LVF-NIR spectrometer has a wide application prospect in the field of non-invasive anemia diagnosis.
- Non-invasive detection,
- Hemoglobin,
- Near-infrared spectroscopy,
- Support vector regression,
- Portable device
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沈阳化工大学材料科学与工程学院沈阳 110142