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Citation: LU Qin-Wei, TONG Ling, LI Dong-Xiang, XU Feng-Guo. Metabolomics Research on Compound Danshen Dripping Pills in Acute Myocardial Infarction Rat[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(6): 791-798. doi: 10.11895/j.issn.0253-3820.170026 shu

Metabolomics Research on Compound Danshen Dripping Pills in Acute Myocardial Infarction Rat

1.
Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;
2.
State Key laboratory of Core Technology in Innovative Chinese Medzhongicine, Tasly Institute, Tianjin 300410, China

Received Date: 13 January 2017
Revised Date: 11 April 2017

An acute myocardial infarction rat model was established by ligation of the left ventricular coronary artery. Plasma samples of rats were collected and analyzed by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) to study the myocardial protection mechanism of compound Danshen dropping pill (CDDP). After principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), 22 metabolites were identified as potential biomarker of AMI. Furthermore, CDDP had remarkable effect on AMI rats. p-Tolyl sulfate, hippuric acid, equol 7-O-glucuronide, lysoPC(16:0), cholic acid, oleamide, palmitic amide and SM(d18:1/16:0) were significantly changed in treatment group. The results showed that CDDP had a very good myocardial protection effect on AMI rats, and might influence the pathways of phenylalanine metabolism, glycerophospholipid metabolism, fatty acid metabolism, primary bile acid biosynthesis and Sphingolipid metabolism.
- Compound Danshen dripping pills,
- Acute myocardial infarction,
- Metabolomics,
- Plasma
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