Citation: SHEN Hong-Ling, MENG Qing-Yan, JIA Xu, LIU Wen-Jie. Combination of High Performance Liquid Chromatography with Nano-electrospray ionization Chirp Z Transform Ion Mobility Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(6): 809-816. doi: 10.11895/j.issn.0253-3820.160859 shu

Combination of High Performance Liquid Chromatography with Nano-electrospray ionization Chirp Z Transform Ion Mobility Spectrometry

1.
College of Life Science, Tarim University, Alar 843300, China;
2.
Key Laboratory of Protection & Utilization of Biological Resources in Tarim Basin of Xinjiang Production and Construction Corps, Alar 843300, China

Received Date: 24 November 2016
Revised Date: 27 March 2017

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 21365018), the International Science &Technology Cooperation Program of XPCC (No.2015AH005), and the Innovation Program of Graduate (No.TDGRI201523).

By combining frequency modulation Chirp Z transform ion mobility spectrometers (IMS) and multi nozzle electrospray array ionization source, a method of NanoESI-Chirp Z transform ion mobility spectrometry-high performance liquid chromatography was developed for the determination of n-alkyl ammonium bromide compounds. The parameters of NanoESI-Chirp Z transform IMS such as electric field intensity, solvent composition, and solution flow rate were investigated and optimized. Subsequently, four kinds of n-alkyl ammonium bromide compounds were respectively detected by this developed Chirp Z transform method and Fourier transform method, and the obtained results were compared. The result indicated that the optimum conditions were electric field intensity of 4.5 kV, and ESI solution flow rate of 8 μL/min. Then a test mixture containing tetrabutylammonium bromide, tetrapentylammoniumbromide, tetrahexylammonium bromide, tetraheptylammonium bromide, tetranoctylammoniumbromideandtetrakis(decyl) ammonium bromide was successfully separated and determined by the HPLC-nanoESI-Chirp Z IMS method.Chirp Z transform method provided higher signal to noise ratio compared to conventional signal averaging method, and was superior to FT method in the determination of drift time.
- Chirp Z transform,
- Ion mobility spectrometry,
- High performance liquid chromatography
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沈阳化工大学材料科学与工程学院沈阳 110142