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Citation: HAN Hong-Xiang, SONG Feng-Rui, SHU Zhen-Bo, LIU Zhi-Qiang, REN Yue-Ying, PI Zi-Feng. An Untargeted Urinary Metabolomics Strategy for Investigation of Therapeutical Mechanism of Schisandra chinensis on Complications of Diabetes Rats[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(3): 389-396. doi: 10.11895/j.issn.0253-3820.160753 shu

An Untargeted Urinary Metabolomics Strategy for Investigation of Therapeutical Mechanism of Schisandra chinensis on Complications of Diabetes Rats

1.
Jilin Agricultural University, College of Chinese medicine, Changchun 130118, China;
2.
National Center for Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
3.
Office of TCM and Biotechnology Pharmacy of Jilin Province, Changchun 130041, China;
4.
China-Japan Union Hospital, Jilin University, Changchun 130033, China

Received Date: 12 October 2016
Revised Date: 21 November 2016

Fund Project: The work was supported by the National Natural Science Foundation of China (Nos. 81373952, 81473537)

An untargeted urinary metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) has been established to investigate the mechanism of Schisandra chinensis in treating diabetes and its complications. The urinary biomarkers related to the therapeutic effects of Schisandra chinensis on the diabetes rats were analyzed. In urine, 28 kinds of endogenous metabolites were identified as potential biomarkers, including 13 endogenous metabolites in positive ion mode, 15 endogenous metabolites in negative ion mode, and hippuric acid detected both in positive and negative ion modes. The results revealed that Schisandra chinensis mainly affected the pathways of pentose and glucuronate interconversions, riboflavin metabolism, pantothenate and CoA biosynthesis, arginine and proline metabolism, intestinal bacteria metabolism, ascorbate and aldarate metabolism and tryptophan metabolism in diabetic rats. Combined with biological analysis of these pathways, the therapeutic mechanism of Schisandra chinensis on diabetes and its complications was verified. Based on the biological function of each pathway, the effect of Schisandra chinensis on diabetic nephropathy is stronger. Moreover, it also has the effects of protecting liver, decreasing fat and antioxidant activity.
- Untargeted metabolomics,
- Schisandra chinensis,
- Diabetes mellitus and its complications,
- Mechanism
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1.
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