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Citation: TANG Tao, ZHANG Wei-Bing, XU Ji-Wei, XIA Ming-Zhu, GONG Xue-Dong, WANG Feng-Yun, LI Tong. Preparation and Evaluation of a C₁₈-Sulfonic Group Dual Modification Chromatographic Stationary Phase[J]. Chinese Journal of Analytical Chemistry, ;2017, 45(1): 56-60. doi: 10.11895/j.issn.0253-3820.160520 shu

Preparation and Evaluation of a C₁₈-Sulfonic Group Dual Modification Chromatographic Stationary Phase

1.
Nanjing University of Science and Technology, Nanjing 210094, China;
2.
East China University of Science and Technology, Shanghai 200237, China;
3.
Dalian Elite Analytical Instruments CO., Ltd., Dalian 116023, China

Received Date: 8 July 2016
Revised Date: 11 October 2016

Fund Project: This work was supported by the National Natural Science Foundation of China (No.51472121) and the National Major Scientific Instruments and Equipments Special Project (No.2012YQ12004401)

A C₁₈-sulfonic group dual modification chromatographic stationary phase was prepared by one-pot reaction to modify the surface of silica with two modifier of octadecyltrichlorosilane (OTS) and trimethoxysilylpropanethiol (MPS) and oxidize the thiol group. Under the optimized reaction conditions, the stationary phase with a mole ratio of 3∶7 between C₁₈ and sulfonic group was obtained. The morphology and feature of the stationary phase were characterized by scanning electronic microscopy, elemental analysis and infrared spectra. The chromatographic properties of the prepared stationary phase were systematically investigated in different separation modes. Five alkyl benzenes and three nucleosides were separated successfully in reversed phase chromatography and hydrophilic interaction chromatography respectively. The bovine serum albumin digests could also be separated well on the stationary phase. The results indicated that the prepared mixed-mode stationary phase could provide multiple separation mechanism and had potential advantages in separating complex samples and adjusting the selectivity.
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Preparation and Evaluation of a C₁₈-Sulfonic Group Dual Modification Chromatographic Stationary Phase