Citation: XIE Xiu-Man, SUN Wan-Yang, HUANG Jing-Yi, Navaneethakrishnan Polachi, TONG Ling, SUN Guo-Xiang. Preparative-High Performance Liquid Chromatography-based Multi-Dimensional Chromatography and Its Application in Traditional Chinese Medicine Research[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(7): 1140-1147. doi: 10.11895/j.issn.0253-3820.160004 shu

Preparative-High Performance Liquid Chromatography-based Multi-Dimensional Chromatography and Its Application in Traditional Chinese Medicine Research

1.
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China;
2.
Tasly Pharmaceutical Analysis Institute Tianjin Tasly Group Co., Ltd., Tianjin 300402, China

Received Date: 4 January 2016
Revised Date: 23 February 2016

Fund Project: This work was supported by the National Major Scientific and Technological Special Project for "Significant New Drugs Development" during the Twelfth Five-year Plan Period (No.2013 zx09402202)

Separation of the active ingredients of Chinese medicine is always difficult due to its complexity matrix. Recent years, the preparative-high performance liquid chromatography (Pre-HPLC)-based multidimensional chromatography combined with the characteristics of different separation technology improved the separation capability and efficiency, and was applied to the separation and purification of complex traditional Chinese medicine (TCM). In this review, the based principle, separation mode and key technology of preparative-HPLC-based multidimensional chromatography, as well as its application in TCM research were introduced.
- Preparative-high performance liquid chromatography,
- Traditional Chinese medicine,
- Multidimensional chromatography,
- Solvent compatibility,
- Interface technology,
- Review
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1.
沈阳化工大学材料科学与工程学院沈阳 110142