Citation: TIAN Cai-Yan, DING Xue-Lu, YIN Jin-Wei, DUAN Yi-Xiang. Preliminary Study of Microfabricated Glow Discharge Plasma Used for Mass Spectrometry Imaging[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(1): 8-12. doi: 10.11895/j.issn.0253-3820.150787 shu

Preliminary Study of Microfabricated Glow Discharge Plasma Used for Mass Spectrometry Imaging

TIAN Cai-Yan ^1,2 ,
DING Xue-Lu ^1,2 ,
YIN Jin-Wei ^1,2 ,
DUAN Yi-Xiang ^1,2,3

1.
¹ College of Life Science, Sichuan University, Chengdu 610064, China;
2.
² Research Center of Analytical Instrumentation, Sichuan University, Chengdu 610064, China;
3.
³ Key Laboratory of Bio-resource and Eco-environment Ministry of Education, Sichuan University, Chengdu 610064, China

Received Date: 10 October 2015
Available Online: 4 November 2015

To evaluate the ability of microfabricated glow discharge plasma (MFGDP) as ion source used for mass spectrometry imaging, the different handwritings with urea added were analyzed, and the spatial distribution of stearic acid and the ramification of quercetin in a slice of winter jujube were explored. The MFGDP was independently researched and developed by our lab, and acted as ion source to absorb and ionize the sample. The mass spectra of the excited sample ions entered into mass spectrometer were converted into corresponding image by special software. The results showed that the MFGDP source was feasible and valuable for mass spectrometry imaging. The method proposed here has remarkable features such as simple device, easy operation, low temperature plasma and time saving (<20 min) and it could be used to locate the distribution of the different substances in a sample. The factors influenced the definition of image were discussed and the experimental conditions were optimized, and the resolution was about 300 μm under the optimum conditions. The technology can distinguish different handwritings according to the
- Micro-fabricated glow discharge plasma,
- Mass spectrometry,
- Scan,
- Imaging
1. [1]
  1 Nemes P, Vertes A. TRAC-Trend. Anal. Chem., 2012,34:22-34
2. [2]
  2 Handberg E, Chingin K, Wang N, Dai X, Chen H. Mass Spectrom. Rev., 2015,34 (6):641-658
3. [3]
  3 Vickerman J C. Analyst., 2011,136. 2199-2217
4. [4]
  4 Pacholski M L, Winograd N. Chem. Rev., 1999,99 (10):2977-3006
5. [5]
  5 Bennet R V, Gamage C M, Fernández F M. J. Vis. Exp., 2013,(77):50575
6. [6]
  6 XIONG Xing-Chuang, FANG Xiang, OUYANG Zheng, JIANG You, HUANG Ze-Jian, ZHANG Yu-Kui. Chinese J. Anal. Chem., 2012,40(1):43-49 熊行创, 方向, 欧阳证, 江游, 黄泽建, 张玉奎.分析化学,2012,40(1):43-49
7. [7]
  7 WEI Kai-Hua, ZHANG Xue-Min, YANG Song-Cheng. J. Instr. Anal., 2007, S1:18-20 魏开华, 张学敏, 杨松成.分析测试学报,2007,S1:18-20
8. [8]
  8 ZHANG Ying, CHEN Gang, LU Hao-Jie, YANG Peng-Yuan. J. Mass Spectrom. Society, 2008,28(4):209-213 张莹, 陈岗, 陆豪杰, 杨芃原.质谱学报,2008,28(4):209-213
9. [9]
  9 Luc V V, Annemie A, Renaat G. Mass Spectrom. Rev., 1999,18:1-47
10. [10]
  10 Bennett R V, Gamage C M, Galhena A S, Fernández F M. Anal. Chem., 2014,86(8):3756-3763
11. [11]
  11 Chen L, Yoshimura K, Yu Z, Iwata R, Ito H, Suzuki H, Mori K, Ariyada O, Takeda S, Hiraoka K. Mass Spectrom., 2009,44(10):1469-1477
12. [12]
  12 Nemes P, Vertes A. J. Vis Exp., 2010,(43):2097
13. [13]
  13 Galhena A S, Harris G A, Nyadong L, Murray K K, Fernández F M. Anal. Chem., 2010,82(6):2178-2181
14. [14]
  14 Maldonado-Torres M, López-Hernández J F, Jiménez-Sandoval P, Winkler R. J. Proteomics., 2014,102:60-65
15. [15]
  15 Li M, Jia B, Ding L, Hong F, Ouyang Y, Chen R, Zhou S, Chen H, Fang X. J. Mass Spectrom., 2013,48(9):1042-1049
16. [16]
  16 Sampson J S, Muddiman D C. Rapid Commun. Mass Spectrom., 2009,23:1989-1992
17. [17]
  17 Nemes P, Vertes A. TRAC-Trend. Anal. Chem., 2012,34:22-34
18. [18]
  18 Girod M, Shi Y, Cheng J X, Cooks R G. Anal. Chem., 2010,83:207-215
19. [19]
  19 Ding X, Zhan X, Yuan X, Zhao Z, Duan Y. Anal. Chem., 2013,85(19):9013-9020
20. [20]
  20 Wang B, Ding X, Zhao Z, Duan Y. Int. J. Mass Spectrom., 2015,377:507-514
21. [21]
  21 HUANG Yan-Feng, KANG Yan, WANG Yong-Chan, ZHANG Ping. Stor. Proc., 2008,8(6):22-24 黄艳凤, 康妍, 王永婵, 张平.保鲜与加工,2008,8(6):22-24
22. [22]
  22 ZHANG Qiong, ZHOU Guang-Fang, SHEN Guang-Ning, ZHU En-Yuan, WANG Hong-Qing. Acta Hort. Sin., 2010,2:193-198 张琼, 周广芳, 沈广宁, 祝恩元, 王红清.园艺学报,2010,2:193-198
1. [1]
  Wei Shao , Wanqun Zhang , Pingping Zhu , Wanqun Hu , Qiang Zhou , Weiwei Li , Kaiping Yang , Xisheng Wang . Design and Practice of Ideological and Political Cases in the Course of Instrument Analysis Experiment: Taking the GC-MS Experiment as an Example. University Chemistry, 2024, 39(2): 147-154. doi: 10.3866/PKU.DXHX202309048
2. [2]
  Donghui PAN , Yuping XU , Xinyu WANG , Lizhen WANG , Junjie YAN , Dongjian SHI , Min YANG , Mingqing CHEN . Preparation and in vivo tracing of ⁶⁸Ga-labeled PM_2.5 mimetic particles for positron emission tomography imaging. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 669-676. doi: 10.11862/CJIC.20230468
3. [3]
  Liang TANG , Jingfei NI , Kang XIAO , Xiangmei LIU . Synthesis and X-ray imaging application of lanthanide-organic complex-based scintillators. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1892-1902. doi: 10.11862/CJIC.20240139
4. [4]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423
5. [5]
  Yingran Liang , Fei Wang , Jiabao Sun , Hongtao Zheng , Zhenli Zhu . Construction and Application of a New Experimental Device for Determination of Alkaline Metal Elements by Plasma Atomic Emission Spectrometry Based on Solution Cathode Glow Discharge: An Alternative Approach for Fundamental Teaching Experiments in Emission Spectroscopy. University Chemistry, 2024, 39(5): 380-387. doi: 10.3866/PKU.DXHX202312024
6. [6]
  Kexin Dong , Chuqi Shen , Ruyu Yan , Yanping Liu , Chunqiang Zhuang , Shijie Li . Integration of Plasmonic Effect and S-Scheme Heterojunction into Ag/Ag₃PO₄/C₃N₅ Photocatalyst for Boosted Photocatalytic Levofloxacin Degradation. Acta Physico-Chimica Sinica, 2024, 40(10): 2310013-. doi: 10.3866/PKU.WHXB202310013
7. [7]
  Tieping CAO , Yuejun LI , Dawei SUN . Surface plasmon resonance effect enhanced photocatalytic CO₂ reduction performance of S-scheme Bi₂S₃/TiO₂ heterojunction. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 903-912. doi: 10.11862/CJIC.20240366
8. [8]
  Zian Lin , Yingxue Jin . Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Disease Marker Screening and Identification: A Comprehensive Experiment Teaching Reform in Instrumental Analysis. University Chemistry, 2024, 39(11): 327-334. doi: 10.12461/PKU.DXHX202403066
9. [9]
  Qingchao Liu , Chunmei Liu , Youcai Lu , Zongpei Zhang , Zhaohui Li . Scanning Electron Microscopy in Higher Education: Bridging Educational Innovation and Scientific Collaboration. University Chemistry, 2025, 40(7): 308-314. doi: 10.12461/PKU.DXHX202408087
10. [10]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
11. [11]
  Lingbang Qiu , Jiangmin Jiang , Libo Wang , Lang Bai , Fei Zhou , Gaoyu Zhou , Quanchao Zhuang , Yanhua Cui . 原位电化学阻抗谱监测长寿命热电池Nb₁₂WO₃₃正极材料的高温双放电机制. Acta Physico-Chimica Sinica, 2025, 41(5): 100040-. doi: 10.1016/j.actphy.2024.100040
12. [12]
  Zhaoxuan ZHU , Lixin WANG , Xiaoning TANG , Long LI , Yan SHI , Jiaojing SHAO . Application of poly(vinyl alcohol) conductive hydrogel electrolytes in zinc ion batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 893-902. doi: 10.11862/CJIC.20240368
13. [13]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
14. [14]
  Hao Wu , Zhen Liu , Dachang Bai . ¹H NMR Spectrum of Amide Compounds. University Chemistry, 2024, 39(3): 231-238. doi: 10.3866/PKU.DXHX202309020
15. [15]
  Chongjing Liu , Yujian Xia , Pengjun Zhang , Shiqiang Wei , Dengfeng Cao , Beibei Sheng , Yongheng Chu , Shuangming Chen , Li Song , Xiaosong Liu . Understanding Solid-Gas and Solid-Liquid Interfaces through Near Ambient Pressure X-Ray Photoelectron Spectroscopy. Acta Physico-Chimica Sinica, 2025, 41(2): 100013-. doi: 10.3866/PKU.WHXB202309036
16. [16]
  Jiandong Liu , Zhijia Zhang , Mikhail Kamenskii , Filipp Volkov , Svetlana Eliseeva , Jianmin Ma . Research Progress on Cathode Electrolyte Interphase in High-Voltage Lithium Batteries. Acta Physico-Chimica Sinica, 2025, 41(2): 100011-. doi: 10.3866/PKU.WHXB202308048
17. [17]
  Xianyong Lu , Tao Hu . Developing an Innovative Inorganic Chemistry Teaching Model Based on Aerospace Specialty Characteristics. University Chemistry, 2025, 40(7): 127-131. doi: 10.12461/PKU.DXHX202409037
18. [18]
  Xinran Zhang , Siqi Liu , Yichi Chen , Qingli Zou , Qinghong Xu , Yaqin Huang . From Protein to Energy Storage Materials: Edible Gelatin Jelly Electrolyte. University Chemistry, 2025, 40(7): 255-266. doi: 10.12461/PKU.DXHX202408104
19. [19]
  Changsheng An , Tao Liu . 在锂金属电位下解析固体电解质界面膜(SEI)的化学机理. Acta Physico-Chimica Sinica, 2025, 41(9): 100101-. doi: 10.1016/j.actphy.2025.100101
20. [20]
  Zhuoming Liang , Ming Chen , Zhiwen Zheng , Kai Chen . Multidimensional Studies on Ketone-Enol Tautomerism of 1,3-Diketones By ¹H NMR. University Chemistry, 2024, 39(7): 361-367. doi: 10.3866/PKU.DXHX202311029

Get Citation

PDF

XML

Metrics

PDF Downloads(16)
Abstract views(699)
HTML views(46)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142