Citation: GUO Da-Peng, WANG Yong-Huan, XU Tian-Bai, ZHANG Yuan, LI Ling-Feng, CHEN Jin-Kai, WANG Xiao-Zhi, LI Peng, LUO Ji-Kui. Rapid Determination of Phenylalanine by Micro-chip based Field Asymmetric Waveform Ion Mobility Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(4): 617-624. doi: 10.11895/j.issn.0253-3820.150708 shu

Rapid Determination of Phenylalanine by Micro-chip based Field Asymmetric Waveform Ion Mobility Spectrometry

1.
¹ Department of Information Science & Electronic Engineering, Zhejiang University, Hangzhou 310027, China;
2.
² Suzhou Wei Mu Intelligent System Ltd., Suzhou 215163, China

Corresponding author: WANG Xiao-Zhi,
Received Date: 6 September 2015
Available Online: 31 October 2015
Fund Project: 本文系国家自然科学基金青年基金(No.61301046) (No.61301046)浙江省公益性技术应用研究计划项目(No.2013C31023) (No.2013C31023)

Field asymmetric ion mobility spectrometry(FAIMS) technology was used for the rapid analysis of phenylalanine(PHE) using a metal diffusion tube-microchip FAIMS system. The test pressure was set at 250 kPa, and the temperature of the gas generator for the diffusion tube was at 190℃. The ion characteristic spectra were acquired under the optimized conditions with a gas flow rate of 2000 mL/min, a dispersion voltage of 152.8 V and a compensation voltage value of-0.62 V for phenylalanine in positive mode. Phenylalanine gas samples with different concentrations were analyzed by FAIMS. The results showed that the ion intensity was linearly correlated to phenylalanine concentration in the range from 6 mg/L to 20 mg/L, and the limit of detection for phenylalanine was 5.9 mg/L. This investigation shows the feasibility of FAIMS technique for rapid detection of phenylalanine. The FAIMS instrument is simple and sensitive, and can be used for rapid detection of phenylalanine.
- Phenylalanine,
- Rapid Determination,
- Field asymmetric ion mobility spectrometry,
- Metal diffusion tube
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