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Citation: Xin-hua Wan, Xian-hong Wang. Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition[J]. Acta Polymerica Sinica, ;2019, 50(2): 99-101. doi: 10.11777/j.issn1000-3304.2019.19006 shu

Catalytic System for Superfast Polypeptide Synthesis under Atmosphere Condition

Xin-hua Wan ^1,, ,
Xian-hong Wang ^2,,

1.
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, Department of College of Chemistry and Molecular Engineering, Peking University, Beijing 100871
2.
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Corresponding author: Xin-hua Wan, xhwanepku.edu.cn Xian-hong Wang, xhwang@eiac.jd.cn
Received Date: 10 January 2019
Available Online: 17 January 2019

Polypeptides (α-amino acid polymers), as one of the most promising biomedical polymers, have excellent biocompatibility, bioactivities and biodegradability. Primary amine-initiated NCA polymerization is the most widely used method to prepare polypeptides. However, this polymerization is super sensitive to moisture, with slow reaction rate and side reactions, and difficult to obtain polypeptides with high molecular weight. Recently, Prof. Liu et al. at East China University of Science and Technology utilized Lithium Hexamethyldisilazide (LiHMDS) as the catalyst to initiate ring opening polymerization of NCA. This is the first demonstration of moisture insensitive NCA polymerization under atmosphere condition. This NCA polymerization can be completed within a few minutes to a few hours and successfully produces poly-BLG with number average molecular weight over 2.8 × 10⁵ g/mol. This research opens the era for easy and efficient synthesis of polypeptides and builds the foundation for large-scale application of polypeptides as biomedical materials.
- Polypeptides,
- N-Carboxyanhydrides (NCA),
- Superfast polymerization,
- Atmosphere condition
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