Citation: Yu-xia Liu, Lie Chen, Zi-guang Zhao, Ruo-chen Fang, Ming-jie Liu. Design and Synthesis of Bioinspired Multiscale Hydrogels: from Interface to Three-dimensional Network[J]. Acta Polymerica Sinica, ;2018, 0(9): 1155-1174. doi: 10.11777/j.issn1000-3304.2018.18108 shu

Design and Synthesis of Bioinspired Multiscale Hydrogels: from Interface to Three-dimensional Network

School of Chemistry, Beihang University, Beijing 100191

Corresponding author: Ming-jie Liu, liumj@buaa.edu.cn
Received Date: 18 April 2018
Revised Date: 9 May 2018
Available Online: 6 September 2018

Hydrogels are three-dimensional polymeric networks with large amount of water as the dispersion medium. The hydrogen bonds between polymer networks and water bind water in the networks, thus making the system lose its fluidity and transform quasi-solid substances. Hydrogel materials can greatly change their shape and volume in response to diverse stimuli, and thus have attracted considerable attention due to their promising applications in soft robots, flexible electronics and sensors. In biological soft tissues, the existence of multi-scale structures, for example, surface micro/nano structures and ordered three-dimensional network structures is crucial to provide biological materials with functionalities, including self-cleaning, freezing tolerance, adaptivity and excellent mechanical performance. Taking inspiration from nature, researchers have increasingly developed a series of bioinspired multiscale hydrogels with high adaptability to various mechanical and environmental conditions. In this review, we first introduce the history of hydrogel. Secondly, the relationship between natural gel materials and their excellent function are summarized. Then the recent researches of bioinspired multi-scale hydrogels focusing on hydrogel ’s surfaces and three-dimensional network designing are discussed. As we mentioned, surface chemical/physical modification and micro/nano structure construction are typical strategies, which can adjust the wettability and adhesion behaviors of hydrogel surface, thus expanding the application of hydrogel in the fields of biomedicine and marine antifouling. In addition, the strategies of three-dimensional networks’ designing, such as introducing non-covalent cross-linking, designing ordered network structure and fabricating heterogeneous networks, are introduced respectively. These strategies can give hydrogels excellent properties including self-healing, anisotropy, high strength, shape memory and freezing tolerance. The development of these biomimetic multiscale hydrogels has expanded the application of hydrogel materials in the fields of wearable devices, software robots, and complex environments. Finally, the current challenges about design of hydrogels’ network, the dispersion of heterogeneous networks, the non-destructive characterization of hydrogels and future perspectives in this field will also be discussed.
- Bioinspired hydrogels,
- Multiscale,
- Interface,
- Three-dimensional network
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