Citation: Jin-feng Zeng, Wen-di Yang, Dong-jian Shi, Xiao-jie Li, Ming-qing Chen. Preparation and Photo-thermal Properties of Thermo-sensitive Injectable Hydrogels Based on Chitosan and Au Nanoparticles[J]. Acta Polymerica Sinica, ;2018, 0(10): 1297-1306. doi: 10.11777/j.issn1000-3304.2018.18048 shu

Preparation and Photo-thermal Properties of Thermo-sensitive Injectable Hydrogels Based on Chitosan and Au Nanoparticles

Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122

Corresponding author: Dong-jian Shi, djshi@jiangnan.edu.cn
Received Date: 5 February 2018
Revised Date: 28 March 2018
Available Online: 24 May 2018

Multiple injections of drugs are generally needed to continuously and effectively kill pathological cells during tumor therapeutic. However, this strategy might induce some side effects. Gold nanoparticles are one kind of photothermal agents that can convert the absorbed light energy into heat energy. This conversion could be used to photo-thermal therapy (PTT), which has property of multiple treatment for killing the tumor cells effectively and completely without other effects. Herein, this study aims to prepare injectable hydrogels with PTT property based on chitosan (CS), β-glycerophosphate (β-GP) and gold nanoparticles (Au NPs) for improving efficiency of anti-tumour. Firstly, CS bio-polymer stabilized Au NPs (CS-Au NPs) were directly reduced in situ by CS. Size of the CS-Au NPs could be controlled at 15 nm. Then, β-glycerophosphate (β-GP) was added into the CS-Au NPs. The mixture of CS-Au NPs and β-GP was sol state at room temperature, which could be injected into the tumor site. And then, at physiological temprature (37 °C), this sol could convert to gel (CGP/Au NPs) via the interactions between CS and β-GP, indicating that the (CGP/Au NPs) gel had the temperature sensitivity. Due to the surface plasmon resonance effect (SPR) of Au NPs, the (CGP/Au NPs) hydrogels showed an excellent photo-thermal property. The temperature of the (CGP/Au NPs) gel rised to above 45 °C and further to approximately 55 °C under Laser irradiation, with increasing amout of Au NPs. Moreover, the photo-thermal ability could be kept for several cycles with repeated laser irradiation. Because of easily fixing CGP hydrogels into biological tissue, Au NPs could be immobilized on the tumor site for a long time for multiple PTT. Thus, the strategies of muiliple drug-injection and blood circulation could be changed with the help of CGP hydrogels. Additionally, Au NPs were distributed evenly in the CGP hydrogels and the (CGP/Au NPs) hydrogels had good stability. Cell viability showed that the gels had excellent biocompatibility to the normal cells, and could kill remarkably the cancer cells with laser irradiation. Meanwhile, the prepared thermo-sensitive hydrogels had good biodegradability. Due to these characteristics, this (CGP/Au NPs) hydrogel might have the potential application to achieve " one time injection, multiple treatments” for tumor therapy.
- Thermo-sensitive hydrogels,
- Photo-thermal therapy,
- Gold nanoparticles
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