Citation: Jia-xun Wan, Lu-yan Sun, Chang-chun Wang. Assembly of Functional Ligands on the Surface of Magnetic Composite Microspheres Based on Gold and Thiol Interaction[J]. Acta Polymerica Sinica, ;2018, 0(8): 1073-1080. doi: 10.11777/j.issn1000-3304.2018.17319 shu

Assembly of Functional Ligands on the Surface of Magnetic Composite Microspheres Based on Gold and Thiol Interaction

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438

Corresponding author: Chang-chun Wang, ccwang@fudan.edu.cn
Received Date: 24 November 2017
Revised Date: 19 December 2017
Available Online: 13 April 2018

Multifunctional magnetic nano-carriers, with high saturation magnetization, high drug-loading and rapid response for external magnetic field, have been widely applied in biomedical fields, such as bioimaging, targeting therapy, diagnostics and so on. In this study, a new efficient way for superficial modification of magnetic composite microspheres based on strong interaction between gold nanoparticles and thiol compounds was explored. Using the distilled-precipitation polymerization technique, we firstly constructed magnetic composite microspheres, (MSP@P(MAA-Cy), with acid-dissolvable magnetic supraparticles (MSP) as the core and a redox-degradable poly(methylacrylic acid-co-N,N-bis(acryloyl)cystamine) (P(MAA-Cy) as the shell, gold nanoparticles (AuNP) with the size of 10 − 30 nm were then deposited onto the surface of the MSP@P(MAA-Cy) microspheres. Through control of the reaction parameters in the distilled-precipitation polymerization, uniform polymer shell with the thickness of 30 − 40 nm was obtained. In addition, the amount and the size of the AuNP particle on the surface of MSP@P(MAA-Cy) microspheres could be adjusted by manipulating the ratio of the raw materials and reaction parameters. With an increase in the feeding amount of gold precursor, i.e. the feeding molar ratio of HAuCl₄ to sodium citrate dihydrate (keep constant in all recipes) changed from 1:20 to 1:5, the particle size of the AuNP increased. Meanwhile, prolonging reaction time also could increase the density and particle szie of the AuNP. Due to the strong interaction between the thiol-modified fluorescent ligands and gold nanoparticles on the surface of MSP@P(MAA-Cy)-AuNP, single or dual fluorescent ligands (FA-PEG-SH and Rho-PEG-SH) could be easily assembled onto the surface of the magnetic polymer composite microspheres by one-step reaction, and the amount of the fluorescent ligands regulated by a convenient and fast way, which should give a new stratagy for onsite-assembly of functional ligands on the surface of magnetic composite microspheres without any post-treatment for personalized targeting cancer therapy.
- Magnetic supraparticles,
- Gold nanoparticles,
- Composite microspheres,
- Fluorescent molecules,
- Onsite-modification,
- High-effective assembly
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