Citation: Jianhui Chen, Renping Ma, Dan Yang, Ruiwen Tian, Longlong Cui, Wang Guan, Yan Liu, Dianpeng Qi, Gongwei Tian, Chengyu Wang. Adhesive flexible bioelectronics: Current status and future challenges[J]. Chinese Chemical Letters, ;2026, 37(12): 112773. doi: 10.1016/j.cclet.2026.112773 shu

Adhesive flexible bioelectronics: Current status and future challenges

Jianhui Chen ^{b, 1} ,
Renping Ma ^{d, 1} ,
Dan Yang ^b ,
Ruiwen Tian ^b ,
Longlong Cui ^b ,
Wang Guan ^b ,
Yan Liu ^b ,
Dianpeng Qi ^{b, c, *,} ,
Gongwei Tian ^{a, **,} ,
Chengyu Wang ^{a, **,}

a.
Key Laboratory of Bio-based Material Science and Technology of Ministry of Education, Northeast Forestry University, Harbin 150040, China
b.
MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, National and Local Joint Engineering Laboratory for Synthesis Transformation and Separation of Extreme Environmental Nutrients, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China
c.
Key Laboratory of Science and Engineering for the Multi-modal Prevention and Control of Major Chronic Diseases, Ministry of Industry and Information Technology, Zhengzhou Research Institute of Harbin Institute of Technology, Zhengzhou 450000, China
d.
Beijing Vocational College of Labour and Social Security, Beijing 100029, China

^**

dpqi@hit.edu.cn

tiangongwei521@163.com

wangcy@nefu.edu.cn

Received Date: 26 October 2025
Revised Date: 6 March 2026
Accepted Date: 14 April 2026
Available Online: 15 April 2026

Figures(7)

Adhesive flexible bioelectronics play an important role in the field of bioelectronic medicine. For example, adhesive flexible bioelectronics can not only be used to monitor electrophysiological signals to diagnose neurological diseases, but also to treat neurological diseases or promote wound healing through electrical stimulation. Existing reviews on adhesive flexible bioelectronics only focuses on conductive hydrogel adhesive. In fact, in addition to the conductive hydrogel adhesive used to enhance the adhesion between flexible bioelectronics and tissues, polymer elastomer substrates with adhesion and hydrogel adhesives are employed as the substrate of flexible electronics, endowing flexible electronics with adhesion to tissue. In this paper, polymer elastomer with adhesion as the substrate of bioelectronics, the hydrogel adhesive as the substrate, and the conductive hydrogel adhesive as the bioelectronics are discussed. respectively. Among them, the strategies for endowing polymer elastomers with adhesion include constructing micro nano structures and modifying hydrophilic groups; the hydrogel adhesive as substrates does not need to consider the conductivity and swelling because it only needs to adjust adhesion and swelling performance, and cannot be used for transmission signal; conductive hydrogel adhesive as flexible bioelectronics not only needs to regulate adhesion, but also enhance conductivity, swell resistance, achieve anti-adhesion, and self-healing properties. Finally, the challenges and future opportunities of adhesive flexible bioelectronics are considered.
- Adhesive flexible bioelectronics,
- Micro nano structure,
- Polymer elastomer,
- Conductive hydrogel adhesive,
- Substrate
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沈阳化工大学材料科学与工程学院沈阳 110142