Citation: Wenwen Zhang, Ziyi Ke, Jian Hu, Yuefei Zhang, Wei Chen, Sheng Tang. Synergistic bimetallic MOF-LDH composite: A multifunctional stationary phase for universal chromatographic separations[J]. Chinese Chemical Letters, ;2026, 37(12): 112723. doi: 10.1016/j.cclet.2026.112723 shu

Synergistic bimetallic MOF-LDH composite: A multifunctional stationary phase for universal chromatographic separations

School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, China

stang@wit.edu.cn

Received Date: 19 September 2025
Revised Date: 26 December 2025
Accepted Date: 2 April 2026
Available Online: 4 April 2026

Figures(4)

A critical challenge of porous metal-organic framework (MOF) such as zirconium-based PCN-224 lies in its constrained separation selectivity due to single-metal active sites. To address this limitation, incorporating transition metal ions into porphyrinic ligands enables the creation of bimetallic MOF (BMOF) with multiple interaction mechanisms. Nevertheless, the utility of BMOF in chromatographic separation is often hindered by inherent mass transfer resistance within its microporous structures. In contrast, layered double hydroxide (LDH) enables superior mass transfer by virtue of hierarchical channels, while offering high hydrophilicity and significant ion-exchange capacity. In this study, a novel multimodal PCN-224(Co)/LDH@SiO₂ stationary phase was developed through the synergistic integration of BMOF with LDH. The etching-induced partial conversion of PCN-224(Co) into LDH produced a composite that preserved the high surface area of BMOF and suppressed the self-aggregation of LDH. The resulting composite combined the hydrophobic character of BMOF ligands with the hydrophilic and ion-exchange properties of LDH to yield synergistic multimodal functionality. The PCN-224(Co)/LDH@SiO₂ stationary phase demonstrated the ability to efficiently separate nucleosides under challenging high-water-content conditions. A systematic mechanistic study utilizing a diverse set of compounds uncovered multiple coexisting retention mechanisms. Furthermore, the PCN-224(Co)/LDH@SiO₂ exhibited robust performance across complex sample matrices, as evidenced by the sensitive detection of polycyclic aromatic hydrocarbons in ophthalmic solutions and vitamin B1 in tablets. This work pioneers a BMOF-LDH hybrid stationary phase, thereby establishing a versatile platform for efficient multi-component separations.
- Metal-organic framework,
- Layered double hydroxide,
- Liquid chromatography,
- Stationary phase,
- Mixed-mode chromatography
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