Citation: Jia-Sheng Wang, Lin-Heng He, Yan-Ting Liu, Yu-Ting Wu, Hai-Tao Zhu, Sheng-Hua Wang, Yu-Yu Tan, Wei-Min He, Yong-Hong Zhang. Synergistic homogeneous photochemical and halogen-bond catalysis toward antitumor sulfonylated fused (hetero)arenes[J]. Chinese Chemical Letters, ;2026, 37(5): 112373. doi: 10.1016/j.cclet.2026.112373 shu

Synergistic homogeneous photochemical and halogen-bond catalysis toward antitumor sulfonylated fused (hetero)arenes

Jia-Sheng Wang ^{a, c, 1} ,
Lin-Heng He ^{c, 1} ,
Yan-Ting Liu ^a ,
Yu-Ting Wu ^a ,
Hai-Tao Zhu ^d ,
Sheng-Hua Wang ^{b, *,} ,
Yu-Yu Tan ^{c, *,} ,
Wei-Min He ^{c, *,} ,
Yong-Hong Zhang ^{a, *,}

a.
Department of Ophthalmology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
b.
School of Chemical and Environmental Engineering, Hunan Institute of Technology, Hengyang 421002, China
c.
School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
d.
College of Chemistry and Material, Baoji University of Arts and Sciences, Baoji 721013, China

wangshenghua0731@163.com

tanyuyu@usc.edu.cn

weiminhe@usc.edu.cn

2020030018@usc.edu.cn

Received Date: 17 November 2025
Revised Date: 30 December 2025
Accepted Date: 6 January 2026
Available Online: 6 January 2026

Figures(7)

A homogeneous dual catalytic system that synergistically merges photochemical and halogen-bond catalysis has been developed for the radical sulfonylation-annulation of (hetero)arene-tethered alkynes and alkenes with RSO₂Cl. This protocol efficiently constructs a variety of sulfonylated fused-(hetero)arenes with good functional group compatibility under mild and eco-friendly conditions. The process is initiated by halogen-bond activation of RSO₂Cl, which facilitates subsequent photocatalyzed heterolytic S-Cl cleavage via a SET pathway to generate RSO₂ radicals; an alternative EnT pathway for radical generation was also identified.
- Homogeneous photocatalysis,
- Halogen-bond organocatalysis,
- Dual catalysis,
- Sulfonyl chlorides,
- Phenanthrene
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