Citation: Mingxuan Zhang, Xingcheng Pan, Jiajie Li, Hang Wang. mRNA-based therapeutics in skin regeneration and rejuvenation: From optimization strategies to translational advances[J]. Chinese Chemical Letters, ;2026, 37(12): 112358. doi: 10.1016/j.cclet.2026.112358 shu

mRNA-based therapeutics in skin regeneration and rejuvenation: From optimization strategies to translational advances

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Cosmetic and Plastic Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

543017408@qq.com

dr_wanghang@scu.edu.cn

Received Date: 18 April 2025
Revised Date: 26 December 2025
Accepted Date: 3 January 2026
Available Online: 5 January 2026

Figures(3)

This paper explores the application of messenger RNA (mRNA) therapy in skin regeneration and rejuvenation. It highlights the unique advantages of mRNA therapeutics, including transient protein expression, non-genomic integration, and scalable manufacturing. Facing challenges, progress in chemical modifications, delivery systems, and biomaterial scaffolds have significantly enhanced mRNA stability, delivery efficiency, and safety, paving the way for clinical applications. Innovative transdermal delivery platforms, particularly lipid nanoparticles (LNPs) and microneedles (MNs) offer enhanced skin penetration, prolonged retention, and controlled release of mRNA cargo. LNPs provide structural stability and efficient cellular uptake, while MNs enable minimally invasive, pain-free delivery, overcoming skin barriers. The applications section reviews recent advances in mRNA therapies to promote wound healing and combat skin aging. Preclinical studies demonstrate that nanocarriers loaded with mRNAs have shown efficacy and safety in accelerating wound healing by stimulating angiogenesis and epidermal cell migration. mRNA-based therapeutics have also shown great potential in increasing collagen and elastin synthesis. Although challenges remain in the regulation of long-term efficacy and standardization of mass production, the field is offering solutions ranging from acute wound healing to chronic photoaging reversal. By focusing on the potential of mRNA therapy in skin regeneration applications, this review discusses its impacts on dermatology and prospects in regenerative medicine.
- mRNA therapy,
- Skin regeneration,
- Skin rejuvenation,
- Wound healing,
- Anti-aging,
- Transdermal delivery
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沈阳化工大学材料科学与工程学院沈阳 110142