Citation: Zhanzhan Feng, Shuyan Zhou, Xiao Li, Guoquan Wan, Kaiyan Xu, Zhiyong Qian. Current advances in the proteolysis-targeting chimeras (PROTACs) delivery systems[J]. Chinese Chemical Letters, ;2026, 37(12): 112338. doi: 10.1016/j.cclet.2025.112338 shu

Current advances in the proteolysis-targeting chimeras (PROTACs) delivery systems

Zhanzhan Feng ^{a, 1} ,
Shuyan Zhou ^{a, 1} ,
Xiao Li ^{a, 1} ,
Guoquan Wan ^{a, b, 1} ,
Kaiyan Xu ^{c, 1} ,
Zhiyong Qian ^{a, *,}

a.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Pharmacy, The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang), Nanchang 330008, China
c.
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

anderson-qian@163.com

Received Date: 28 September 2025
Revised Date: 24 December 2025
Accepted Date: 28 December 2025
Available Online: 29 December 2025

Figures(2)

Proteolysis-targeting chimeras (PROTACs) represent a transformative therapeutic approach but face clinical translation hurdles due to high molecular weight, poor physicochemical properties, and off-target risks. We present a comprehensive review and analysis of various current PROTAC delivery strategies. These strategies fall into three main categories: Nanocarrier-based systems utilizing polymers, liposomes, and other materials, often with stimuli-responsive control; biomacromolecular platforms based on antibodies, peptides, or nucleic acids; and novel chemical methods such as prodrug modifications through esterification or photocaging. All three approaches have been developed to enhance delivery efficiency and specificity. Finally, this review outlines prospective future directions toward intelligent and precise delivery systems. These systems hold promise for expanding the spectrum of degradable undruggable targets and facilitate novel combination therapies. Collectively, these advancements provide valuable theoretical insights and practical guidance for the clinical translation of PROTACs.
- PROTACs,
- Drug delivery systems,
- Nanoparticles,
- Prodrugs,
- Stimulus-responsive
1. [1]
  W. Zhao, Y. Jiang, X. Li, et al., Wires Nanomed. Nanobiotechnol. 16 (2024) e2020. doi: 10.1002/wnan.2020
2. [2]
  Z. Li, P. Song, Y. Liu, et al., Chin. Chem. Lett. 37 (2026) 111033. doi: 10.1016/j.cclet.2025.111033
3. [3]
  KM S., KB K., A K., et al., Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8554–8559. doi: 10.1073/pnas.141230798
4. [4]
  R.B. Damgaard, Cell Death. Differ. 28 (2021) 423–426. doi: 10.1038/s41418-020-00703-w
5. [5]
  X. Liang, H. Ren, F. Han, et al., Med. Res. Rev. 44 (2024) 632–685. doi: 10.1002/med.21992
6. [6]
  D. Sun, J. Zhang, G. Dong, et al., J. Med. Chem. 65 (2022) 14276–14288. doi: 10.1021/acs.jmedchem.2c01159
7. [7]
  J. Liu, H. Chen, H.Ü. Kaniskan, et al., J. Am. Chem. Soc. 143 (2021) 8902–8910. doi: 10.1021/jacs.1c03852
8. [8]
  B.L. Zerfas, Y. Liu, J. Che, et al., RSC Med. Chem. 16 (2025) 2460–2466. doi: 10.1039/d5md00028a
9. [9]
  A.S. Alhallaq, N.S. Sultan, Mol. Biol. Rep. 52 (2025) 804. doi: 10.1007/s11033-025-10917-1
10. [10]
  Y. Lv, G. Dai, B. Zhang, et al., J. Med. Chem. 68 (2025) 16593–16612. doi: 10.1021/acs.jmedchem.5c01463
11. [11]
  E. Price, M. Weinheimer, A. Rivkin, et al., J. Med. Chem. 67 (2024) 5683–5698. doi: 10.1021/acs.jmedchem.3c02332
12. [12]
  V. Poongavanam, Y. Atilaw, S. Siegel, et al., J. Med. Chem. 65 (2022) 13029–13040. doi: 10.1021/acs.jmedchem.2c00877
13. [13]
  Y. Feng, C. Chen, A. Shao, et al., Chin. Chem. Lett. 36 (2025) 110963. doi: 10.1016/j.cclet.2025.110963
14. [14]
  Z. Wang, B.S. Pan, R.K. Manne, et al., Cell 188 (2025) 3219–3237. doi: 10.1016/j.cell.2025.03.036
15. [15]
  J.M.L. Casan, J.F. Seymour, Blood 143 (2024) 1218–1230. doi: 10.1182/blood.2023022993
16. [16]
  T.H. Pillow, P. Adhikari, R.A. Blake, et al., ChemMedChem. 15 (2020) 17–25. doi: 10.1002/cmdc.201900497
17. [17]
  S. He, Y. Fang, M. Wu, et al., J. Med. Chem. 66 (2023) 16828–16842. doi: 10.1021/acs.jmedchem.3c01539
18. [18]
  B. Ma, D. Liu, Z. Wang, et al., J. Med. Chem. 67 (2024) 10336–10349. doi: 10.1021/acs.jmedchem.4c00828
19. [19]
  S. He, F. Gao, J. Ma, et al., Angew. Chem. Int. Ed. 60 (2021) 23299–23305. doi: 10.1002/anie.202107347
20. [20]
  Y. Fang, Q. Wu, F. Wang, et al., Small. Methods 9 (2025) e2400349. doi: 10.1002/smtd.202400349
21. [21]
  A. Nathani, M. Aare, L. Sun, et al., Pharmaceutics. 16 (2024) 1070. doi: 10.3390/pharmaceutics16081070
22. [22]
  L. Huang, X. Sun, Q. Zuo, et al., Mater. Today Bio 31 (2025) 101523. doi: 10.1016/j.mtbio.2025.101523
23. [23]
  M. Wolosowicz, S. Prokopiuk, T.W. Kaminski, Int. J. Mol. Sci. 25 (2024) 13691. doi: 10.3390/ijms252413691
24. [24]
  X. Zhao, Y. Li, Pharmaceuticals 18 (2025) 1042. doi: 10.3390/ph18071042
25. [25]
  H.T. Zhang, R. Peng, S. Chen, et al., Adv. Sci. 9 (2022) e2202039. doi: 10.1002/advs.202202039
26. [26]
  W. Wang, C. Zhu, B. Zhang, et al., J. Am. Chem. Soc. 145 (2023) 16642–16649. doi: 10.1021/jacs.3c04109
27. [27]
  F. Wang, G. Dong, M. Ding, et al., Small. 20 (2024) e2306378. doi: 10.1002/smll.202306378
28. [28]
  Y. He, X. Zan, J. Miao, et al., Mater. Today Bio 16 (2022) 100423. doi: 10.1016/j.mtbio.2022.100423
29. [29]
  B. Gong, W. Zhang, W. Cong, et al., Adv. Healthc. Mater. 13 (2024) e2400149. doi: 10.1002/adhm.202400149
30. [30]
  K. Li, G. Dong, S. Wu, et al., Chin. Chem. Lett. 36 (2025) 110280. doi: 10.1016/j.cclet.2024.110280
31. [31]
  T. Hu, C. Shen, X. Wang, et al., Chin. Chem. Lett. 35 (2024) 109562. doi: 10.1016/j.cclet.2024.109562
32. [32]
  J.M. Morachis, E.A. Mahmoud, A. Almutairi, Pharmacol. Rev. 64 (2012) 505–519. doi: 10.1124/pr.111.005363
33. [33]
  R. Cheng, F. Meng, C. Deng, et al., Biomaterials 34 (2013) 3647–3657. doi: 10.1016/j.biomaterials.2013.01.084
34. [34]
  J. Nicolas, S. Mura, D. Brambilla, et al., Chem. Soc. Rev. 42 (2013) 1147–1235. doi: 10.1039/C2CS35265F
35. [35]
  A. Saraswat, M. Patki, Y. Fu, et al., Nanomedicine 15 (2020) 1761–1777. doi: 10.2217/nnm-2020-0156
36. [36]
  F.J. Cimas, E. Niza, A. Juan, et al., Pharmaceutics. 12 (2020) 986. doi: 10.3390/pharmaceutics12100986
37. [37]
  Z.F. Zou, L. Yang, H.J. Nie, et al., Acta Pharmacol. Sin. 45 (2024) 1740–1751. doi: 10.1038/s41401-024-01266-z
38. [38]
  Y. He, Y. Ju, Y. Hu, et al., J. Control. Release 354 (2023) 155–166. doi: 10.1016/j.jconrel.2022.12.035
39. [39]
  Y. Sun, L. Jiang, Z. Zhang, et al., ACS Appl. Mater. Interfaces 16 (2024) 19987–19994.
40. [40]
  O. Koshkina, T. Rheinberger, V. Flocke, et al., Nat. Commun. 14 (2023) 4351. doi: 10.1038/s41467-023-40089-0
41. [41]
  C. Zhang, Z. Zeng, D. Cui, et al., Nat. Commun. 12 (2021) 2934. doi: 10.1038/s41467-021-23194-w
42. [42]
  C. Zhang, S. He, Z. Zeng, et al., Angew. Chem. Int. Ed. 61 (2022) e202114957. doi: 10.1002/anie.202114957
43. [43]
  J. Gao, B. Hou, Q. Zhu, et al., Nat. Commun. 13 (2022) 4318. doi: 10.1038/s41467-022-32050-4
44. [44]
  F. Pöstges, K. Kayser, J. Appelhaus, et al., Pharmaceutics. 15 (2023) 156. doi: 10.3390/pharmaceutics15010156
45. [45]
  X. Cheng, S. Hu, K. Cheng, ACS Nano 17 (2023) 11855–11868. doi: 10.1021/acsnano.3c03166
46. [46]
  J. Ma, L. Fang, Z. Sun, et al., Adv. Healthc. Mater. 13 (2024) e2400109. doi: 10.1002/adhm.202400109
47. [47]
  H.J. Liu, W. Chen, G. Wu, et al., Adv. Sci. 10 (2023) e2207439. doi: 10.1002/advs.202207439
48. [48]
  X. Guan, X. Xu, Y. Tao, et al., J. Nanobiotechnol. 22 (2024) 692. doi: 10.1186/s12951-024-02967-7
49. [49]
  Z. Li, G. Ren, X. Wang, et al., Biomaterials 322 (2025) 123387. doi: 10.1016/j.biomaterials.2025.123387
50. [50]
  L. Yang, Y. Yang, J. Zhang, et al., Signal. Transduct. Target. Ther. 9 (2024) 275.
51. [51]
  Z. Chen, Y. Tai, C. Deng, et al., Biomaterials 321 (2025) 123344. doi: 10.1016/j.biomaterials.2025.123344
52. [52]
  J. Chen, F. Ma, Y. Zhang, et al., Adv. Funct. Mater. 34 (2024) 2314203. doi: 10.1002/adfm.202314203
53. [53]
  X. Wang, J. Yan, Y. Zhao, et al., ACS Appl. Mater. Interfaces 17 (2025) 20943–20956. doi: 10.1021/acsami.5c01103
54. [54]
  Y. Wu, X. Chang, G. Yang, et al., Adv. Mater. 35 (2023) e2210787. doi: 10.1002/adma.202210787
55. [55]
  H. Cabral, Y. Matsumoto, K. Mizuno, et al., Nat. Nanotechnol. 6 (2011) 815–823. doi: 10.1038/nnano.2011.166
56. [56]
  M.J. Mitchell, M.M. Billingsley, R.M. Haley, et al., Nat. Rev. Drug Discov. 20 (2021) 101–124. doi: 10.1038/s41573-020-0090-8
57. [57]
  T.G. Floyd, P. Gurnani, J.Y. Rho, Nanoscale 17 (2025) 7738–7752. doi: 10.1039/d5nr00071h
58. [58]
  L. Eltaib, Polymers 17 (2025) 833. doi: 10.3390/polym17070833
59. [59]
  L. Zheng, B. Hu, D. Zhao, et al., Chin. Chem. Lett. 35 (2024) 108647. doi: 10.1016/j.cclet.2023.108647
60. [60]
  C. Kahlert, R. Kalluri, J. Mol. Med. 91 (2013) 431–437. doi: 10.1007/s00109-013-1020-6
61. [61]
  R. Kalluri, V.S. LeBleu, Science 1979 367 (2020) 6478.
62. [62]
  N. Mukerjee, S. Maitra, A. Ghosh, et al., Drug Dev. Res. 84 (2023) 1031–1036. doi: 10.1002/ddr.22091
63. [63]
  N. Erwin, U. De, Y. Xiao, et al., bioRxiv. (2024), doi:10.1101/2024.08.25.609564. doi: 10.1101/2024.08.25.609564
64. [64]
  J. Wang, D. Chen, E.A. Ho, J. Control. Release 329 (2021) 894–906. doi: 10.1016/j.jconrel.2020.10.020
65. [65]
  S.S. Palakurthi, B. Shah, S. Kapre, et al., Nanoscale Adv. 6 (2024) 5803–5826. doi: 10.1039/d4na00501e
66. [66]
  Z. Iqbal, K. Rehman, A. Mahmood, et al., J. Nanobiotechnol. 22 (2024) 395. doi: 10.1186/s12951-024-02634-x
67. [67]
  E.W. Syahputra, H. Lee, H. Cho, et al., Pharmaceutics. 17 (2025) 501. doi: 10.3390/pharmaceutics17040501
68. [68]
  L. Li, C. Wang, Q. Li, et al., Cytokine Growth Factor Rev. 73 (2023) 135–149. doi: 10.1016/j.cytogfr.2023.07.007
69. [69]
  X. Hou, T. Zaks, R. Langer, et al., Nat. Rev. Mater. 6 (2021) 1078–1094. doi: 10.1038/s41578-021-00358-0
70. [70]
  P. Kou, E.S. Levy, A.D. Nguyen, et al., Pharmaceutics. 15 (2023) 2098. doi: 10.3390/pharmaceutics15082098
71. [71]
  X. Chen, F. Li, B. Cui, et al., Int. J. Pharm. 668 (2025) 124973. doi: 10.1016/j.ijpharm.2024.124973
72. [72]
  X. Wang, L. Su, C. Niu, et al., Drug Dev. Res. 85 (2024) e22241. doi: 10.1002/ddr.22241
73. [73]
  A. Saraswat, H.P. Vemana, V.V. Dukhande, et al., Heliyon. 8 (2022) e08702. doi: 10.1016/j.heliyon.2021.e08702
74. [74]
  W. Zhang, Y. Jin, J. Wang, et al., J. Colloid. Interface Sci. 678 (2025) 896–907. doi: 10.1016/j.jcis.2024.08.185
75. [75]
  H. Zhang, X. Xu, D. Yan, et al., ACS Appl. Mater. Interfaces 15 (2023) 8946–8957. doi: 10.1021/acsami.2c20312
76. [76]
  R. Vartak, K. Patel, J. Control. Release 376 (2024) 502–517. doi: 10.1016/j.jconrel.2024.10.007
77. [77]
  A. Saraswat, R. Vartak, R. Hegazy, et al., Biomed. Pharmacother. 168 (2023) 115754. doi: 10.1016/j.biopha.2023.115754
78. [78]
  J. Chen, M. Qiu, F. Ma, et al., J. Control. Release 330 (2021) 1244–1249. doi: 10.1016/j.jconrel.2020.11.032
79. [79]
  Y. Fu, D. Rathod, K. Patel, Exp. Cell Res. 396 (2020) 112275. doi: 10.1016/j.yexcr.2020.112275
80. [80]
  X. Wang, Y. Zhao, X. Li, et al., Nano Lett. 24 (2024) 4858–4868.
81. [81]
  T. Luo, Q. Zheng, L. Shao, et al., Angew. Chem. Int. Ed. 61 (2022) e202206277. doi: 10.1002/anie.202206277
82. [82]
  A. Chan, R.M. Haley, M.A. Najar, et al., Nat. Commun. 15 (2024) 5808. doi: 10.1038/s41467-024-50235-x
83. [83]
  Q. Xu, X. Hu, I. Ullah, et al., Adv. Mater. 37 (2025) e2504253. doi: 10.1002/adma.202504253
84. [84]
  T.B. Gandek, L. van der Koog, A. Nagelkerke, Adv. Healthc. Mater. 12 (2023) e2300319. doi: 10.1002/adhm.202300319
85. [85]
  N. Zhao, L. Yan, X. Zhao, et al., Chem. Rev. 119 (2019) 1666–1762. doi: 10.1021/acs.chemrev.8b00401
86. [86]
  B. Ma, Y. Fan, D. Zhang, et al., Adv. Sci. 9 (2022) e2201859. doi: 10.1002/advs.202201859
87. [87]
  Z. Wang, M. Tan, W. Su, et al., J. Med. Chem. 66 (2023) 6263–6273. doi: 10.1021/acs.jmedchem.3c00013
88. [88]
  Y. Wang, L. Han, F. Liu, et al., Colloid Surf. B 188 (2020) 110795. doi: 10.1016/j.colsurfb.2020.110795
89. [89]
  Z. Li, T. Jiang, X. Yuan, et al., J. Control. Release 374 (2024) 441–453. doi: 10.15541/jim20230539
90. [90]
  F. Niu, R. Yang, H. Feng, et al., Biochem. Biophys. Res. Commun. 684 (2023) 149125. doi: 10.1016/j.bbrc.2023.149125
91. [91]
  L. Fang, R. Zhu, M. Li, et al., Eur. J. Pharm. Biopharm. 210 (2025) 114699. doi: 10.1016/j.ejpb.2025.114699
92. [92]
  Q. He, L. Zhou, D. Yu, et al., J. Med. Chem. 66 (2023) 10458–10472. doi: 10.1021/acs.jmedchem.3c00587
93. [93]
  J. Zhan, X. Li, Y. Mu, et al., Biomater. Sci. 12 (2024) 3686–3699. doi: 10.1039/d4bm00548a
94. [94]
  M. Tan, X. Li, L. Cheng, et al., Adv. Mater. 37 (2025) e2412837. doi: 10.1002/adma.202412837
95. [95]
  H. Zhu, F. Gao, Y. Li, et al., Nano Today 56 (2024) 102308. doi: 10.1016/j.nantod.2024.102308
96. [96]
  S. Xu, B. Ma, Y. Jian, et al., EBioMedicine 104 (2024) 105162. doi: 10.1016/j.ebiom.2024.105162
97. [97]
  M. Liong, J. Lu, M. Kovochich, et al., ACS Nano 2 (2008) 889–896. doi: 10.1021/nn800072t
98. [98]
  R M., MA D., D.L. Cheney, et al., Adv. Drug Deliv. Rev. 144 (2019) 112–132. doi: 10.17511/ijphr.2019.i3.03
99. [99]
  D.C. Luther, R. Huang, T. Jeon, et al., Adv. Drug Deliv. Rev. 156 (2020) 188–213. doi: 10.1016/j.addr.2020.06.020
100. [100]
  Y.Y. Yu, W. Hu, Y. Xu, et al., J. Control. Release 382 (2025) 113719. doi: 10.1016/j.jconrel.2025.113719
101. [101]
  W. Gao, X. Xia, X. Yang, et al., Chem. Eng. J. 495 (2024) 153437. doi: 10.1016/j.cej.2024.153437
102. [102]
  Q. Li, X. Yang, M. Zhao, et al., Nano Res. 17 (2024) 9954–9964. doi: 10.1007/s12274-024-6974-x
103. [103]
  T. Wang, Y. Zhang, K. Chen, et al., Nano Today 50 (2023) 101890. doi: 10.1016/j.nantod.2023.101890
104. [104]
  F. Zhang, K. Cui, Y. Zhou, et al., Nano Today 62 (2025) 102678. doi: 10.1016/j.nantod.2025.102678
105. [105]
  J. Lin, W. Wang, A.K. Ying, et al., J. Control. Release 384 (2025) 113921. doi: 10.1016/j.jconrel.2025.113921
106. [106]
  F. Tong, Y. Wang, Y. Xu, et al., Nat. Commun. 15 (2024) 10382. doi: 10.1038/s41467-024-54854-2
107. [107]
  N. Chen, Z. Zhang, X. Liu, et al., J. Am. Chem. Soc. 146 (2024) 10753–10766. doi: 10.1021/jacs.4c00826
108. [108]
  Z. Lin, B.A. Garcia, D. Lv, Angew. Chem. Int. Ed. 63 (2024) e202316581. doi: 10.1002/anie.202316581
109. [109]
  R. Fan, S. He, Y. Wang, et al., Am. J. Cancer Res. 12 (2022) 1027–1041.
110. [110]
  S. Wang, Z. Feng, C. Qu, et al., J. Med. Chem. 67 (2024) 9842–9856. doi: 10.1021/acs.jmedchem.3c02340
111. [111]
  C. Chen, Y. Yang, Z. Wang, et al., J. Med. Chem. 66 (2023) 8428–8440. doi: 10.1021/acs.jmedchem.3c00302
112. [112]
  M. Wei, R. Zhao, Y. Cao, et al., Eur. J. Med. Chem. 209 (2021) 112903. doi: 10.1016/j.ejmech.2020.112903
113. [113]
  Y. Li, Y. Guo, S. Ma, et al., ACS Omega 10 (2025) 23926–23942. doi: 10.1021/acsomega.5c01241
114. [114]
  G. Xue, K. Wang, D. Zhou, et al., J. Am. Chem. Soc. 141 (2019) 18370–18374. doi: 10.1021/jacs.9b06422
115. [115]
  Z. Li, S. Ma, X. Yang, et al., Eur. J. Med. Chem. 222 (2021) 113608. doi: 10.1016/j.ejmech.2021.113608
116. [116]
  J. Liu, H. Chen, Y. Liu, et al., J. Am. Chem. Soc. 143 (2021) 7380–7387. doi: 10.1021/jacs.1c00451
117. [117]
  H. Chen, J. Liu, H. Kaniskan, et al., J. Med. Chem. 64 (2021) 12273–12285. doi: 10.1021/acs.jmedchem.1c00901
118. [118]
  J. Huang, Z. Yao, B. Li, et al., J. Control. Release 361 (2023) 270–279. doi: 10.1016/j.jconrel.2023.07.062
119. [119]
  M. Chang, Y. Dong, H. Xu, et al., Angew. Chem. Int. Ed. 63 (2024) e202315425. doi: 10.1002/anie.202315425
120. [120]
  K. An, X. Deng, H. Chi, et al., Angew. Chem. Int. Ed. 62 (2023) e202306824. doi: 10.1002/anie.202306824
121. [121]
  N. Hofmann, M. Harms, K. Mäder, Int. J. Pharm. 650 (2024) 123725. doi: 10.1016/j.ijpharm.2023.123725
122. [122]
  V. Meloni, L. Halstenberg, L. Mareczek, et al., Pharmaceutics. 16 (2024) 1499. doi: 10.3390/pharmaceutics16121499
123. [123]
  R. Wang, T. Zhong, Q. Bian, et al., Small Methods 7 (2023) e2201293. doi: 10.1002/smtd.202201293
1. [1]
  Mengdie Li , Shundong Cai , Hongjin Li , Yuhang Cheng , Jinfa Ye , Lang Ke , Yun Han , Min Su , Gang Liu , Chengchao Chu . Nanotherapeutics for ocular posterior segment diseases therapy: Towards its advances and challenges. Chinese Chemical Letters, 2026, 37(5): 111392-. doi: 10.1016/j.cclet.2025.111392
2. [2]
  Hailong He , Wenbing Wang , Wenmin Pang , Chen Zou , Dan Peng . Double stimulus-responsive palladium catalysts for ethylene polymerization and copolymerization. Chinese Chemical Letters, 2024, 35(7): 109534-. doi: 10.1016/j.cclet.2024.109534
3. [3]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
4. [4]
  Zhongxin Duan , Yue Wang , Yunchu Zhang , Xia Liu , Wanyu Wang , Hua Li , Qingyang Lu , Chao You , Yongzhong Cheng , Cong Wu , Xiang Gao . Intranasal pterostilbene nanoparticles delivery alleviates neuroinflammation and brain injury after intracerebral hemorrhage. Chinese Chemical Letters, 2026, 37(5): 111248-. doi: 10.1016/j.cclet.2025.111248
5. [5]
  Yue Wang , Zhongxin Duan , Huabin Zhang , Xia Liu , Qingyang Lu , Hua Li , Yunchu Zhang , Jiaqi Zheng , Wenyi Zhan , Mingze Du , Xifeng Zhang , Xiang Gao , Yunxiang Ji . Intranasal delivery of rosiglitazone-loaded chitosan nanoparticles promotes erythrocyte phagocytosis and alleviates brain injury after intracerebral hemorrhage. Chinese Chemical Letters, 2026, 37(12): 112336-. doi: 10.1016/j.cclet.2025.112336
6. [6]
  Zhi Li , Wenpei Li , Shaoping Jiang , Chuan Hu , Yuanyu Huang , Maxim Shevtsov , Huile Gao , Shaobo Ruan . Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention. Chinese Chemical Letters, 2024, 35(7): 109150-. doi: 10.1016/j.cclet.2023.109150
7. [7]
  Yiyao Wan , Wen Chen , Yan Yu , Meng Pan , Kun Shi , Zhiyong Qian . Biomaterial-based drug delivery systems for the therapy of malignant pleural effusion. Chinese Chemical Letters, 2026, 37(1): 111513-. doi: 10.1016/j.cclet.2025.111513
8. [8]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
9. [9]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
10. [10]
  Yang Liu , Jing Liang , Mengzhu Zheng , Haoze Song , Lixia Chen , Hua Li . PD-L1/SHP2 dual PROTACs inhibit melanoma by enhancing T-cell killing activity. Chinese Chemical Letters, 2025, 36(6): 110317-. doi: 10.1016/j.cclet.2024.110317
11. [11]
  Lian Jin , Juan Zhang , Libo Nie , Yan Deng , Ghulam Jilany Khana , Nongyue He . Chitosan nanoparticles act as promising carriers of microRNAs to brain cells in neurodegenerative diseases. Chinese Chemical Letters, 2025, 36(10): 110774-. doi: 10.1016/j.cclet.2024.110774
12. [12]
  Yuwen Zhu , Xiang Deng , Yan Wu , Baode Shen , Lingyu Hang , Yuye Xue , Hailong Yuan . Formation mechanism of herpetrione self-assembled nanoparticles based on pH-driven method. Chinese Chemical Letters, 2025, 36(1): 109733-. doi: 10.1016/j.cclet.2024.109733
13. [13]
  Liangyu Zhang , Lei Lei , Zhuangzhuang Zhao , Guizhi Yang , Kaitao Wang , Liying Wang , Ningxin Zhang , Yanjia Ai , Xinqing Ma , Guannan Liu , Meng Zhao , Jun Wu , Dongjun Lin , Chun Chen . Enhanced venetoclax delivery using l-phenylalanine nanocarriers in acute myeloid leukemia treatment. Chinese Chemical Letters, 2025, 36(6): 110316-. doi: 10.1016/j.cclet.2024.110316
14. [14]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
15. [15]
  Wei Su , Xiaoyan Luo , Peiyuan Li , Ying Zhang , Chenxiang Lin , Kang Wang , Jianzhuang Jiang . Phthalocyanine self-assembled nanoparticles for type Ⅰ photodynamic antibacterial therapy. Chinese Chemical Letters, 2024, 35(12): 109522-. doi: 10.1016/j.cclet.2024.109522
16. [16]
  Zhiyuan Huang , Fangqiu Fu , Chaoqiang Deng , Shiyang Wu , Mingxuan Huang , Xianyi Sha , Ming Q Wei , Zhiwen Zhang , Yang Zhang . Strategies of designing lymph nodes-targeting nanoparticles for cancer immunotherapy. Chinese Chemical Letters, 2026, 37(9): 111993-. doi: 10.1016/j.cclet.2025.111993
17. [17]
  Tianxia Chen , Yunhui Chen , Weiwei Li , Peipei Cen , Yan Guo , Jin Zhang , Cunding Kong , Xiangyu Liu . Fabricating AuAg-nanoparticles/ZIF-8 composites for selective detection and efficient extraction of dinitroaniline pesticides. Chinese Chemical Letters, 2025, 36(8): 110214-. doi: 10.1016/j.cclet.2024.110214
18. [18]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
19. [19]
  Shiyang Sun , Ning Yang , Yaqiu Mao , Ting Wei , Pengli Wei , Tingting Yang , Yixin Zhang , Jian Yan , Changkai Jia , Yi Li , Xu Cai , Zhiyuan Zhao , Xuesong Feng , Xiaomei Zhuang , Wenpeng Zhang , Junhai Xiao , Pengyun Li , Zhibing Zheng , Song Li . Rational design of VHL-recruiting KRAS^G12C proteolysis-targeting chimeras based on molecular dynamics simulation. Chinese Chemical Letters, 2026, 37(2): 110992-. doi: 10.1016/j.cclet.2025.110992
20. [20]
  Jiangmin Zhu , Qimei Tan , Shiying Fan , Yalin Li , Ling Zhu , Lihong Hong , Yuxia Wang , Chuzhen Zhang , Chen Chen , Lingyi Kong , Jianguang Luo . PROTAC degraders of FSP1 act as potent GPX4 sensitizers to induce ferroptosis for hepatoma treatment. Chinese Chemical Letters, 2026, 37(5): 111285-. doi: 10.1016/j.cclet.2025.111285

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沈阳化工大学材料科学与工程学院沈阳 110142