Citation: Weilang Zhang, Qixing Dong, Zhangwen Peng, Lina Su, Hongmei Liu, Yunfei Yi, Lin Mei. Advanced nanomaterial-based therapeutic strategies for chronic wound management[J]. Chinese Chemical Letters, ;2026, 37(12): 112264. doi: 10.1016/j.cclet.2025.112264 shu

Advanced nanomaterial-based therapeutic strategies for chronic wound management

Weilang Zhang ^{a, b} ,
Qixing Dong ^c ,
Zhangwen Peng ^d ,
Lina Su ^{e, *,} ,
Hongmei Liu ^f ,
Yunfei Yi ^{g, *,} ,
Lin Mei ^{a, b, g, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Furong Laboratory, Central South University, Changsha 410008, China
c.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
d.
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China
e.
Department of Pharmacy, Qujing University of Medicine & Health Sciences, Qujing 655000, China
f.
Engineering Research Center of Medical Biotechnology, School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, China
g.
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

sulina828@163.com

b2023015006@pumc.edu.cn

meilin@bme.pumc.edu.cn

Received Date: 6 May 2025
Revised Date: 9 December 2025
Accepted Date: 10 December 2025
Available Online: 11 December 2025

Chronic wounds represent a significant healthcare challenge, particularly for populations such as the elderly, diabetics, and individuals with poor immune function. Various factors contribute to the failure of chronic wound healing, including oxidative stress, impaired vascularization, infection, and prolonged inflammation. Traditional wound care methods, such as routine dressing changes, antibiotics, and debridement, primarily focus on infection control and basic protection, but reckoning without balanced coordination of complex pathological factors and difficulty handling intricate problems such as antibiotic resistance. In this review, we will mainly introduce the emerging advanced therapeutic strategies based on nanomaterials and smart wound dressings that target the underlying pathological causes to accelerate the chronic wound healing process, and will also discuss the current limitations and future perspectives of chronic wound management.
- Chronic wounds,
- Wound healing,
- Advanced therapeutic strategies,
- Nanomaterials,
- Smart wound dressings
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沈阳化工大学材料科学与工程学院沈阳 110142