Citation: Xiaoyu Fan, Ergui Luo, Wenjuan Wang, Zhi Du, Yi Deng, Di Huang. Nanozyme-armed probiotics: Mastering redox modulation for synergistic therapy[J]. Chinese Chemical Letters, ;2026, 37(9): 112058. doi: 10.1016/j.cclet.2025.112058 shu

Nanozyme-armed probiotics: Mastering redox modulation for synergistic therapy

Xiaoyu Fan ^a ,
Ergui Luo ^b ,
Wenjuan Wang ^c ,
Zhi Du ^{a, *,} ,
Yi Deng ^{d, *,} ,
Di Huang ^{a, *,}

a.
Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, Shanxi Key Laboratory of Functional Proteins, College of Artificial Intelligence, Taiyuan University of Technology, Taiyuan 030024, China
b.
Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education, School of Chemistry and Materials Science, Shanxi Normal University, Taiyuan 030032, China
c.
College of Chemistry and Chemical Engineering, Taiyuan University of Technology, Taiyuan 030024, China
d.
School of Chemical Engineering, Sichuan University, Chengdu 610065, China

duzhi@tyut.edu.cn

dengyibandeng@scu.edu.cn

huangjw2067@163.com

Received Date: 31 May 2025
Revised Date: 31 October 2025
Accepted Date: 3 November 2025
Available Online: 3 November 2025

Figures(5)

Probiotics encompass a diverse assortment of biological activities and are widely distributed in barrier organs, which enables them to dynamically modulate multiple physiological processes within the human body. Due to their diminished side effects, a spectrum of probiotic-centric functional formulations has been used as an alternative to traditional anti-inflammatory drugs. Nonetheless, probiotics are intrinsically sensitive to environmental fluctuations, which greatly limits their therapeutic effectiveness. The specific combination of probiotics with nanozymes opens up novel perspectives for resolving this issue. Nanozymes are nanomaterials that exhibit enzyme-like properties, showcasing exceptional catalytic prowess while retaining the distinctive attributes of nanomaterials. The alliance of nanozymes and probiotics demonstrates a significant synergistic effect in the treatment of diseases. On one hand, inherent targeting and metabolic properties of probiotics impart nanozymes with site-selectivity, alongside the capacity to fine-tune the catalytic microenvironment for optimized activity. On the other hand, nanozymes exhibit exceptional catalytic properties that can be leveraged to safeguard probiotics and concurrently bestow new bioactivities, thereby enhancing their therapeutic efficacy. This review underscores the therapeutic potential of nanozyme-enhanced probiotics in regulating reactive oxygen species for the synergetic therapy of various diseases, as well as the challenges associated with the biosafety of such biomimetic functional agents.
- Probiotic,
- Nanozyme,
- Reactive oxygen species,
- Redox homeostasis,
- Site-selective catalysis,
- Chemodynamic therapy,
- Synergetic therapy
1. [1]
  C. Hill, F. Guarner, G. Reid, et al., Nat. Rev. Gastroenterol. Hepatol. 11 (2014) 506–514. doi: 10.1038/nrgastro.2014.66
2. [2]
  S. Lin, F. Wu, Y. Zhang, et al., Chem. Soc. Rev. 52 (2023) 6617–6643. doi: 10.1039/d3cs00369h
3. [3]
  M. Han, W. Lei, J. Liang, et al., Carbohydr. Polym. 324 (2024) 121472. doi: 10.1016/j.carbpol.2023.121472
4. [4]
  H. Chen, Q. Zhao, Q. Zhong, et al., Phenomics 2 (2022) 363–382. doi: 10.1007/s43657-022-00073-y
5. [5]
  A. Latif, A. Shehzad, S. Niazi, et al., Front. Microbiol. 14 (2023) 1216674. doi: 10.3389/fmicb.2023.1216674
6. [6]
  O. Felfoul, M. Mohammadi, S. Taherkhani, et al., Nat. Nanotechnol. 11 (2016) 941–947. doi: 10.1038/nnano.2016.137
7. [7]
  M. Li, S.Y. Li, H. Zhou, et al., Nat. Commun. 11 (2020) 1126. doi: 10.1038/s41467-020-14963-0
8. [8]
  M. Saluja, P. Gilling, Int. J. Urol. 25 (2017) 18–24.
9. [9]
  A. Lee, J.S. Yoo, E.J. Yoon, Antibiotics 13 (2024) 995. doi: 10.3390/antibiotics13100995
10. [10]
  H. Liu, Q. Zhang, S.C. Wang, et al., Bioact. Mater. 14 (2022) 169–181.
11. [11]
  Y. Liu, B. Liu, D. Li, et al., Adv. Funct. Mater. 30 (2020) 2001157. doi: 10.1002/adfm.202001157
12. [12]
  Z. Li, A.M. Behrens, N. Ginat, et al., Adv. Mater. 30 (2018) 1803925. doi: 10.1002/adma.201803925
13. [13]
  K. Liang, Q. Liu, Q. Kong, Biotechnol. Bioeng. 118 (2020) 513–530. doi: 10.3390/mi11050513
14. [14]
  S. Yan, X. Zeng, Y. Wang, B.F. Liu, Adv. Healthcare Mater. 9 (2020) 2000046. doi: 10.1002/adhm.202000046
15. [15]
  L.M. Zhu, T.T. Yu, W.C. Wang, et al., Adv. Mater. 36 (2024) 2308728. doi: 10.1002/adma.202308728
16. [16]
  S. Song, M.S. Vuai, M. Zhong, Infect. Agents Cancer 13 (2018) 9. doi: 10.1057/978-1-137-52436-2_2
17. [17]
  J.X. Fan, M.T. Niu, Y.T. Qin, Y.X. Sun, X.Z. Zhang, Adv. Drug Deliv. Rev. 185 (2022) 114296. doi: 10.1016/j.addr.2022.114296
18. [18]
  X. Wang, Y. Hu, H. Wei, Inorg. Chem. Front. 3 (2016) 41–60. doi: 10.1039/C5QI00240K
19. [19]
  Y.J. Ai, Z.N. Hu, X.P. Liang, et al., Adv. Funct. Mater. 32 (2022) 2110432. doi: 10.1002/adfm.202110432
20. [20]
  H.H. Song, M.L. Zhang, W.J. Tong, Molecules 27 (2022) 5426. doi: 10.3390/molecules27175426
21. [21]
  M. Liang, X. Yan, Acc. Chem. Res. 52 (2019) 2190–2200. doi: 10.1021/acs.accounts.9b00140
22. [22]
  C. Zhang, X. Wang, J. Du, Z. Gu, Y. Zhao, Adv. Sci. 8 (2020) 2002797.
23. [23]
  Y.A. Wang, X.Y. He, K.L. Huang, N. Cheng, J. Nanobiotechnology 22 (2024) 226. doi: 10.1186/s12951-024-02478-5
24. [24]
  H. He, L. Du, H. Xue, et al., Small Methods 7 (2023) e2300230. doi: 10.1002/smtd.202300230
25. [25]
  X. Fang, R. Gong, D. Yang, et al., J. Am. Chem. Soc. 146 (2024) 15251–15263. doi: 10.1021/jacs.4c02530
26. [26]
  X. Cai, Q. Zheng, Y. Wu, X. Cheng, C. Zhu, Chin. Chem. Lett. 37 (2026) 111670. doi: 10.1016/j.cclet.2025.111670
27. [27]
  Y. Wang, H. Fu, B. Huang, et al., Chem. Eng. J. 497 (2024) 155684. doi: 10.1016/j.cej.2024.155684
28. [28]
  H. Fu, Y. Wang, B. Huang, et al., J. Control. Release 380 (2025) 892–909. doi: 10.1016/j.jconrel.2025.02.038
29. [29]
  Y.F. Zhou, Q.Y. Li, Y.H. Wu, et al., Adv. Mater. 36 (2024) 2313953. doi: 10.1002/adma.202313953
30. [30]
  Z. Du, E. Nam, Y. Lin, et al., Chem. Sci. 14 (2023) 5340–5349. doi: 10.1039/d3sc00881a
31. [31]
  G. Bodega, M. Alique, L. Puebla, J. Carracedo, R.M. Ramírez, J. Extracell. Vesicles 8 (2019) 1626654. doi: 10.1080/20013078.2019.1626654
32. [32]
  L.Y. Wang, B.H. Zhu, Y.T. Deng, et al., Adv. Funct. Mater. 31 (2021) 2101804. doi: 10.1002/adfm.202101804
33. [33]
  P. Silwal, J.K. Kim, Y.J. Kim, E.K. Jo, Front. Immunol. 11 (2020) 1649. doi: 10.3389/fimmu.2020.01649
34. [34]
  Y. Yu, S. Liu, L. Yang, et al., MedComm 5 (2024) e519. doi: 10.1002/mco2.519
35. [35]
  C. Glorieux, S.H. Liu, D. Trachootham, P. Huang, Nat. Rev. Drug Discov. 23 (2024) 583–606. doi: 10.1038/s41573-024-00979-4
36. [36]
  S.M. Crusz, F.R. Balkwill, Nat. Rev. Clin. Oncol. 12 (2015) 584–596. doi: 10.1038/nrclinonc.2015.105
37. [37]
  S. Bindu, S. Mazumder, U. Bandyopadhyay, Biochem. Pharmacol. 180 (2020) 114147. doi: 10.1016/j.bcp.2020.114147
38. [38]
  Z. Du, C. Liu, H.L. Song, et al., Chem 6 (2020) 2060–2072. doi: 10.1016/j.chempr.2020.06.002
39. [39]
  W.F. van Zyl, S.M. Deane, L.M.T. Dicks, Gut Microbes 12 (2020) 1831339. doi: 10.1080/19490976.2020.1831339
40. [40]
  A.M. O’Hara, F. Shanahan, EMBO Rep. 7 (2006) 688–693. doi: 10.1038/sj.embor.7400731
41. [41]
  C. Kunst, S. Schmid, M. Michalski, et al., Biomedicines 11 (2023) 1388. doi: 10.3390/biomedicines11051388
42. [42]
  A.M. O’Hara, F. Shanahan, Sci. World J. 7 (2007) 31–46. doi: 10.1100/tsw.2007.26
43. [43]
  X.Y. Ren, D.X. Chen, Y. Wang, et al., J. Nanobiotechnol. 20 (2022) 92. doi: 10.1186/s12951-022-01295-y
44. [44]
  Y. Wang, X. Jia, S. An, et al., Adv. Mater. 36 (2023) 2301810.
45. [45]
  C.Y. Cao, N. Yang, X.R. Wang, et al., Coord. Chem. Rev. 491 (2023) 215245. doi: 10.1016/j.ccr.2023.215245
46. [46]
  H. Shi, Y. Guo, C. Geng, et al., Adv. Funct. Mater. 35 (2024) 2413276.
47. [47]
  D.D. Chen, G.X. Tan, S.H. Tian, et al., Chem. Eng. J. 500 (2024) 157299. doi: 10.1016/j.cej.2024.157299
48. [48]
  V. Aggarwal, H.S. Tuli, A. Varol, et al., Biomolecules 9 (2019) 735. doi: 10.3390/biom9110735
49. [49]
  L. Zhu, M. Luo, Y. Zhang, et al., Coord. Chem. Rev. 475 (2023) 214875. doi: 10.1016/j.ccr.2022.214875
50. [50]
  Y.M. Su, X.M. Zhang, Y. Gu, et al., ACS Appl. Mater. Interfaces 15 (2023) 6354–6370. doi: 10.1021/acsami.2c17366
51. [51]
  W.Y. Dai, R. Shu, F. Yang, et al., Adv. Mater. 36 (2024) 2305277. doi: 10.1002/adma.202305277
52. [52]
  Y. Li, Z. Du, X. Liu, et al., Small 15 (2019) 1901116. doi: 10.1002/smll.201901116
53. [53]
  M.H. Lan, S.J. Zhao, W.M. Liu, et al., Adv. Healthc. Mater. 8 (2019) 1900132. doi: 10.1002/adhm.201900132
54. [54]
  Z. Li, K.B. Grant, RSC Adv. 6 (2016) 24617–24634. doi: 10.1039/C5RA28102D
55. [55]
  A. Ioannou, M.D. Berkhout, S.Y. Geerlings, C. Belzer, Nat. Rev. Microbiol. 23 (2024) 162–177. doi: 10.3390/antiox13020162
56. [56]
  A.L. Brioukhanov, A.I. Netrusov, Appl. Biochem. Microbiol. 43 (2007) 567–582. doi: 10.1134/S0003683807060014
57. [57]
  F.P. Tally, B.R. Goldin, N.V. Jacobus, S.L. Gorbach, Infect. Immun. 16 (1977) 20–25. doi: 10.1128/iai.16.1.20-25.1977
58. [58]
  M. Grisham, Lancet 344 (1994) 859–861. doi: 10.1016/S0140-6736(94)92831-2
59. [59]
  A. Joorabloo, T. Liu, Exploration 4 (2024) 20230066. doi: 10.1002/EXP.20230066
60. [60]
  Y. Dai, Y. Ding, L. Li, Chin. Chem. Lett. 32 (2021) 2715–2728. doi: 10.1016/j.cclet.2021.03.036
61. [61]
  M.G. Rooks, W.S. Garrett, Nat. Rev. Immunol. 16 (2016) 341–352. doi: 10.1038/nri.2016.42
62. [62]
  F. Farjadian, M. Moghoofei, S. Mirkiani, et al., Biotechnol. Adv. 36 (2018) 968–985. doi: 10.1016/j.biotechadv.2018.02.016
63. [63]
  Y. Liu, L. Niu, N. Li, et al., Adv. Sci. 10 (2023) 2205641. doi: 10.1002/advs.202205641
64. [64]
  G. Song, C. Zeng, J. Li, et al., Nanomedicine 20 (2025) 1167–1180. doi: 10.1080/17435889.2025.2493037
65. [65]
  P. Gao, Z. Duan, G. Xu, et al., Adv. Mater. 36 (2024) 2405075. doi: 10.1002/adma.202405075
66. [66]
  C. Villemin, A. Six, B.A. Neville, et al., Trends Immunol. 44 (2023) 44–59. doi: 10.1016/j.it.2022.11.002
67. [67]
  J. Suez, N. Zmora, E. Segal, E. Elinav, Nat. Med. 25 (2019) 716–729. doi: 10.1038/s41591-019-0439-x
68. [68]
  D.R. Plichta, D.B. Graham, S. Subramanian, R.J. Xavier, Cell 178 (2019) 1041–1056. doi: 10.1016/j.cell.2019.07.045
69. [69]
  L.J. Fu, Q. He, X.Y. Lu, et al., Adv. Funct. Mater. 34 (2024) 2405304. doi: 10.1002/adfm.202405304
70. [70]
  H. Zhao, Y. Du, L. Liu, et al., J. Mater. Chem. B 10 (2022) 4002–4011. doi: 10.1039/d2tb00300g
71. [71]
  W.H. Li, J.R. Yang, D.S. Wang, Y.D. Li, Chem 8 (2022) 119–140. doi: 10.1016/j.chempr.2021.10.030
72. [72]
  F. Cao, L. Jin, Y. Gao, et al., Nat. Nanotechnol. 18 (2023) 617–627. doi: 10.1038/s41565-023-01346-x
73. [73]
  D. Lu, Q. Wu, X.S. Xu, et al., Nano Today 55 (2024) 102150. doi: 10.1016/j.nantod.2024.102150
74. [74]
  T. Chen, W. Meng, Y. Li, et al., Nano Lett. 24 (2024) 7321–7331. doi: 10.1021/acs.nanolett.4c01143
75. [75]
  J.F. Yu, S.Y. Li, B. Xiong, et al., Adv. Mater. 37 (2024) 2412429.
76. [76]
  H. Sies, D.P. Jones, Nat. Rev. Mol. Cell Biol. 21 (2020) 363–383. doi: 10.1038/s41580-020-0230-3
77. [77]
  A.T. Dharmaraja, J. Med. Chem. 60 (2017) 3221–3240. doi: 10.1021/acs.jmedchem.6b01243
78. [78]
  E. Panieri, M.M. Santoro, Cell Death Dis. 7 (2016) e2253-e2253. doi: 10.1038/cddis.2016.105
79. [79]
  Y.Y. Huang, J.S. Ren, X.G. Qu, Chem. Rev. 119 (2019) 4357–4412. doi: 10.1021/acs.chemrev.8b00672
80. [80]
  D.W. Jiang, D.L. Ni, Z.T. Rosenkrans, et al., Chem. Soc. Rev. 48 (2019) 3683–3704. doi: 10.1039/c8cs00718g
81. [81]
  L. Jin, F. Cao, Y. Gao, et al., Adv. Mater. 35 (2023) 2301349. doi: 10.1002/adma.202301349
82. [82]
  F. Cao, Y. Sang, C. Liu, et al., ACS Nano 16 (2022) 855–868. doi: 10.1021/acsnano.1c08464
83. [83]
  L. Chen, S. Xing, Y. Lei, et al., Angew. Chem. Int. Ed. 60 (2021) 23534–23539. doi: 10.1002/anie.202107712
84. [84]
  J. Lee, H. Liao, Q. Wang, et al., Exploration 2 (2022) 20210086. doi: 10.1002/EXP.20210086
85. [85]
  F. Cao, L. Jin, C. Zhang, et al., Adv. Mater. 36 (2023) 2304257.
86. [86]
  S.A. Rosenberg, Nature 411 (2001) 380–384. doi: 10.1038/35077246
87. [87]
  T. Nie, Y. Fang, R. Zhang, et al., Bioact. Mater. 47 (2025) 51–63.
88. [88]
  T. Nie, H. Liu, Z. Fang, et al., ACS Nano 17 (2023) 10925–10937. doi: 10.1021/acsnano.3c02803
89. [89]
  D. Wang, W. Fang, C. Huang, et al., Smart Mater. Med. 3 (2022) 159–167.
90. [90]
  A. Ribas, J.D. Wolchok, Science 359 (2018) 1350–1355. doi: 10.1126/science.aar4060
91. [91]
  W. Wang, M. Green, J.E. Choi, et al., Nature 569 (2019) 270–274. doi: 10.1038/s41586-019-1170-y
92. [92]
  M.M. Gubin, X.L. Zhang, H. Schuster, et al., Nature 515 (2014) 577–581. doi: 10.1038/nature13988
93. [93]
  W.Y. Zhang, J.W. Liu, X.Y. Li, et al., ACS Nano 15 (2021) 19321–19333. doi: 10.1021/acsnano.1c05605
94. [94]
  M. Łuksza, N. Riaz, V. Makarov, et al., Nature 551 (2017) 517–520. doi: 10.1038/nature24473
95. [95]
  W. Wang, L. Zhang, Y. Zhang, et al., Adv. Mater. 36 (2024) 2310063. doi: 10.1002/adma.202310063
96. [96]
  K.C. Barnett, S. Li, K. Liang, J.P.Y. Ting, Cell 186 (2023) 2288–2312. doi: 10.1016/j.cell.2023.04.025
97. [97]
  K.V. Swanson, M. Deng, J.P.Y. Ting, Nat. Rev. Immunol. 19 (2019) 477–489. doi: 10.1038/s41577-019-0165-0
98. [98]
  L. Zhang, Q.C. Yang, S. Wang, et al., Adv. Mater. 34 (2022) 2108174. doi: 10.1002/adma.202108174
99. [99]
  Y. Yang, T. Hu, Y. Bian, et al., Adv. Mater. 35 (2023) 2211205. doi: 10.1002/adma.202211205
100. [100]
  A. Koh, F. De Vadder, P. Kovatcheva-Datchary, F. Bäckhed, Cell 165 (2016) 1332–1345. doi: 10.1016/j.cell.2016.05.041
101. [101]
  P. Tripathi, A. Beaussart, D. Alsteens, et al., ACS Nano 7 (2013) 3685–3697. doi: 10.1021/nn400705u
102. [102]
  M. Qin, X. Zhang, H. Ding, et al., Adv. Mater. 36 (2024) 2402530. doi: 10.1002/adma.202402530
103. [103]
  L. Dieltjens, K. Appermans, M. Lissens, et al., Nat. Commun. 11 (2020) 107. doi: 10.1038/s41467-019-13660-x
104. [104]
  G. Wei, Q.Y. Liu, X.Y. Wang, et al., Sci. Adv. 9 (2023) eadg0949. doi: 10.1126/sciadv.adg0949
105. [105]
  M. Dróżdż, S. Makuch, G. Cieniuch, M. Woźniak, P. Ziółkowski, Life Sci. 261 (2020) 118296. doi: 10.1016/j.lfs.2020.118296
106. [106]
  M.Y. Yang, F.W. Yang, W.J. Chen, et al., Biomater. Sci. 9 (2021) 5732–5744. doi: 10.1039/d1bm00634g
107. [107]
  D.d.S. Santos, P.R.d.A. Calaça, A.L.F. Porto, et al., J. Integr. Biol. 24 (2020) 706–713. doi: 10.1089/omi.2020.0078
108. [108]
  P. Veiga, J. Suez, M. Derrien, E. Elinav, Nat. Microbiol. 5 (2020) 878–880. doi: 10.1038/s41564-020-0721-1
109. [109]
  F. Wu, X.M. Xie, T. Du, et al., World J. Microbiol. Biotechnol. 39 (2023) 325. doi: 10.1007/978-3-031-27524-1_31
110. [110]
  J.E. Goldford, N.X. Lu, D. Bajic, et al., Science 361 (2018) 469–474. doi: 10.1126/science.aat1168
111. [111]
  M.T. Mee, J.J. Collins, G.M. Church, H.H. Wang, Proc. Natl. Acad. Sci. U. S. A. 111 (2014) E2149–E2156.
112. [112]
  J.A. Christie-Oleza, D. Sousoni, M. Lloyd, J. Armengaud, D.J. Scanlan, Nat. Microbiol. 2 (2017) 17100. doi: 10.1038/nmicrobiol.2017.100
113. [113]
  B. Liu, Y. Li, Y. Cao, et al., Eur. J. Inorg. Chem. 2019 (2019) 1714–1723. doi: 10.1002/ejic.201801451
114. [114]
  L. Zhang, H. Wang, X. Qu, Adv. Mater. 36 (2023) 2211147.
115. [115]
  S. Zhang, X.J. Gao, Y. Ma, et al., Nat. Commun. 15 (2024) 10605. doi: 10.1038/s41467-024-54868-w
116. [116]
  H.Z. Fan, R.F. Zhang, K.L. Fan, L.Z. Gao, X.Y. Yan, ACS Nano 18 (2024) 2533–2540. doi: 10.1021/acsnano.3c07680
117. [117]
  Z. Zhang, E. Luo, W. Wang, et al., Small 21 (2024) 2408343.
118. [118]
  N. Tagaras, H. Song, S. Sahar, et al., Adv. Sci. 11 (2024) 2407816. doi: 10.1002/advs.202407816
119. [119]
  L. Xuan, Z. Ju, M. Skonieczna, P.K. Zhou, R. Huang, MedComm 4 (2023) e327. doi: 10.1002/mco2.327
120. [120]
  Z. Feng, Y. Guo, Y. Zhang, et al., J. Nanobiotechnol. 22 (2024) 704. doi: 10.1186/s12951-024-02907-5
121. [121]
  W. He, J. Wu, J. Liu, J. Li, Adv. Funct. Mater. 34 (2024) 2312116. doi: 10.1002/adfm.202312116
122. [122]
  S.R. Li, Z.J. Zhou, Z.X. Tie, et al., Nat. Commun. 13 (2022) 827. doi: 10.1038/s41467-022-28344-2
123. [123]
  R. Zhang, X. Yan, K. Fan, Acc. Mater. Res. 2 (2021) 534–547. doi: 10.1021/accountsmr.1c00074
124. [124]
  Z. Zhang, Z. Chen, Y. Zhang, et al., Coord. Chem. Rev. 524 (2025) 216340. doi: 10.1016/j.ccr.2024.216340
1. [1]
  Dou Zhang , Xinyi Cai , Yimin Li , Yong Liu , Long Qiu , Zhenying Diao , Xuyi Liu , Yuta Nishina , Yajuan Zou , Jianbo Sun , Shujing Liang , Daxiang Cui , Ting Yin . Nanozyme with dual enzyme activity mediating cascade catalytic therapy synergize multiple functions for antitumor therapy. Chinese Chemical Letters, 2026, 37(3): 111569-. doi: 10.1016/j.cclet.2025.111569
2. [2]
  Zekun Gao , Xiuli Zheng , Weimin Liu , Jie Sha , Shuaishuai Bian , Haohui Ren , Jiasheng Wu , Wenjun Zhang , Chun-Sing Lee , Pengfei Wang . GSH-activatable copper-elsinochrome off-on photosensitizer for combined specific NIR-Ⅱ two-photon photodynamic/chemodynamic therapy. Chinese Chemical Letters, 2025, 36(3): 109874-. doi: 10.1016/j.cclet.2024.109874
3. [3]
  Leichen Wang , Anqing Mei , Na Li , Xiaohong Ruan , Xu Sun , Yu Cai , Jinjun Shao , Xiaochen Dong . Aza-BODIPY dye with unexpected bromination and high singlet oxygen quantum yield for photoacoustic imaging-guided synergetic photodynamic/photothermal therapy. Chinese Chemical Letters, 2024, 35(6): 108974-. doi: 10.1016/j.cclet.2023.108974
4. [4]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
5. [5]
  Xiaoli Cai , Qihui Zheng , Yu Wu , Xin Cheng , Chengzhou Zhu . H₂O₂ self-supplying cascade catalysis based on single-atom Cu nanozyme for augmented cancer therapy. Chinese Chemical Letters, 2026, 37(4): 111670-. doi: 10.1016/j.cclet.2025.111670
6. [6]
  Zhongyu Wang , Lijun Wang , Huaixin Zhao . DNA-based nanosystems to generate reactive oxygen species for nanomedicine. Chinese Chemical Letters, 2024, 35(11): 109637-. doi: 10.1016/j.cclet.2024.109637
7. [7]
  Xiaoshuai Wu , Bailei Wang , Yichen Li , Xiaoxuan Guan , Mingjing Yin , Wenquan Lv , Yin Chen , Fei Lu , Tao Qin , Huyang Gao , Weiqian Jin , Yifu Huang , Cuiping Li , Ming Gao , Junyu Lu . NIR driven catalytic enhanced acute lung injury therapy by using polydopamine@Co nanozyme via scavenging ROS. Chinese Chemical Letters, 2025, 36(2): 110211-. doi: 10.1016/j.cclet.2024.110211
8. [8]
  Yueru Wei , Qi Miao , Miaomiao Zhang , Wenying Zhang , Mengxiao Shi , Rui Liu , Jingjing Su , Pengchao Sun , Yongxing Zhao . PtCu nanozyme integrating single atom Pt and Pt subnanoclusters for the sustained treatment of cutaneous melanoma. Chinese Chemical Letters, 2025, 36(12): 111164-. doi: 10.1016/j.cclet.2025.111164
9. [9]
  Meng Pan , Dong Mo , Wen Chen , Yun Yang , Qingya Liu , Yujia Wei , Xicheng Li , Hanzhi Deng , Yan Yu , Liping Yuan , Yu Liu , Zhiyong Qian . Ultrasound-augmented chemodynamic and chemotherapy amplify cascade oxidative stress for potentiating immunogenic cell death in pancreatic cancer treatment. Chinese Chemical Letters, 2026, 37(9): 112846-. doi: 10.1016/j.cclet.2026.112846
10. [10]
  Xuan Wu , Ming Liu , Xiao Wang , Jie Niu , Ting-Long Zhuang , Xiaohuan Sun , Liqi Zhu , Quan Zhang , Jie Han , Rong Guo . pH-mediated selective self-assembly in the mitochondria of cancer cells for synergetic ferroptosis. Chinese Chemical Letters, 2026, 37(9): 112198-. doi: 10.1016/j.cclet.2025.112198
11. [11]
  Yongzhi Wu , Rong He , Bowen Tan , Longjiang Li , Jinfeng Liao . An injectable hydrogel for chemodynamic therapy-induced ferroptosis in malignant melanoma. Chinese Chemical Letters, 2026, 37(3): 111339-. doi: 10.1016/j.cclet.2025.111339
12. [12]
  Qiuxia Tan , E Pang , Qin Wang , Yuanyu Tang , Pan Zhu , Shaojing Zhao , Jianing Yi , Shiguang Jin , Minhuan Lan . Manganese carbonate-based nanoplatform for starvation therapy cascaded chemodynamic therapy, enhanced phototherapy and immune activation. Chinese Chemical Letters, 2025, 36(10): 110770-. doi: 10.1016/j.cclet.2024.110770
13. [13]
  Xiaoyi Meng , Xinyue Sun , Zhaogang Sun , Yue Cheng , Yong Wang , Jun Ye , Yin Xiao , Hongqian Chu . Supramolecular-orchestrated carrier-free chemodynamic synergists with augmented oxidative damage for potentiated cancer therapy. Chinese Chemical Letters, 2025, 36(5): 110765-. doi: 10.1016/j.cclet.2024.110765
14. [14]
  Xueying Shi , Xiaoxuan Zhou , Bing Xiao , Hongxia Xu , Wei Zhang , Hongjie Hu , Shiqun Shao , Zhuxian Zhou , Youqing Shen , Xiaodan Xu , Jianbin Tang . A β-lapachone-loaded iron-polyphenol nanocomplex enhances chemodynamic therapy through cascade amplification of ROS in tumor. Chinese Chemical Letters, 2025, 36(5): 110178-. doi: 10.1016/j.cclet.2024.110178
15. [15]
  Guanghui Lin , Jieyao Chen , Xiaojia Liu , Yitong Lin , Xudong Zhu , Guotao Yuan , Bowen Yang , Shuanshuan Guo , Yue Pan , Jianhua Zhou . Sustained modulation of tumor microenvironment via sorafenib-loaded mesoporous ferromanganese nanozymes for enhanced apoptosis-ferroptosis cancer therapy. Chinese Chemical Letters, 2025, 36(8): 111018-. doi: 10.1016/j.cclet.2025.111018
16. [16]
  Yuyao Guan , Baoting Yu , Jun Ding , Tingting Sun , Zhigang Xie . BODIPY photosensitizers for antibacterial photodynamic therapy. Chinese Chemical Letters, 2025, 36(8): 110645-. doi: 10.1016/j.cclet.2024.110645
17. [17]
  Li Qin , Wenjing Wei , Keqing Wang , Xianbao Shi , Guixia Ling , Peng Zhang . Ultrasound-responsive heterojunction sonosensitizers for multifunctional synergistic sonodynamic therapy. Chinese Chemical Letters, 2025, 36(7): 110777-. doi: 10.1016/j.cclet.2024.110777
18. [18]
  Yu-Yang Bi , Ling-Feng Zhang , Qiu Chen , Ming-Yuan Yang , Lei Xing , Hu-Lin Jiang , Xian-Wu Cheng . A heterogeneity-modulated hydrogel for acute and chronic colitis therapy. Chinese Chemical Letters, 2026, 37(8): 111836-. doi: 10.1016/j.cclet.2025.111836
19. [19]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
20. [20]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(8)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142