Citation: Mingjun Yang, Zhongyong Xu, Lei Wang, Mingle Li, Xiaoqiang Chen, Bin Liu, Xiaojun Peng. Real-time analysis of pyriproxyfen using FA1-targeting albumin-based supramolecular probe with enhanced anti-interference performance[J]. Chinese Chemical Letters, ;2026, 37(9): 112028. doi: 10.1016/j.cclet.2025.112028 shu

Real-time analysis of pyriproxyfen using FA1-targeting albumin-based supramolecular probe with enhanced anti-interference performance

College of Material Science and Engineering, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen 518060, China

xzy@szu.edu.cn

bliu@szu.edu.cn

Received Date: 15 July 2025
Revised Date: 23 October 2025
Accepted Date: 27 October 2025
Available Online: 28 October 2025

Figures(5)

Given the widespread use of pyriproxyfen (PPF) in public health and agricultural pest management, accurate residue monitoring is critical to ensuring food safety, preserving ecological equilibrium, and protecting human health. While fluorescent sensing techniques represent promising paradigm for PPF detection, existing probes often lack rapid response and high specificity. To address this issue, we present the development of a novel FA1-targeting albumin-based supramolecular probe (DOCD@ALB) for the ratiometric detection of PPF. The strategy design minimizes competitive interference from DS1-binding compounds (e.g., epicatechin), thereby significantly improving its detection accuracy and specificity. When integrated with a smartphone-assisted portable sensing device, the DOCD@ALB system enables on-site PPF quantification in tea matrices, demonstrating its clear translational potential. These findings highlight the pivotal role of binding site selection in modulating the sensing performance of the supramolecular probe system, offering a robust analytical tool with implications for food safety surveillance and environmental protection.
- Pyriproxyfen,
- Anti-interference,
- Albumin,
- FA1-targeting,
- Supramolecular probes
1. [1]
  K. Kupferschmidt, Science 354 (2016) 171–173. doi: 10.1126/science.354.6309.171
2. [2]
  J.J. Sullivan, K.S. Goh, J. Pestic. Sci. 33 (2008) 339–350. doi: 10.1584/jpestics.R08-02
3. [3]
  L.E. Guzmán, A.N. Wijetunge, B.F. Riske, et al., J. Am. Chem. Soc. 146 (2024) 8480–8485. doi: 10.1021/jacs.3c14598
4. [4]
  M. Accrombessi, J. Cook, E. Dangbenon, et al., Lancet 401 (2023) 435–446. doi: 10.1016/S0140-6736(22)02319-4
5. [5]
  H. Liu, X. Yi, J. Bi, et al., J. Hazard. Mater. 365 (2019) 97–106. doi: 10.3847/1538-4357/ab391c
6. [6]
  J. Feng, Y. Ma, Z. Chen, et al., ACS Sustain. Chem. Eng. 9 (2021) 4988–4999. doi: 10.1021/acssuschemeng.0c08105
7. [7]
  H. Abdourahime, M. Anastassiadou, M. Arena, et al., EFSA J. 17 (2019) 5732.
8. [8]
  GB2763-2021, National food safety standard—Maximum residue limits for pesticides in food, China, 2021, pp. 496.
9. [9]
  G.A. Gómez-Ríos, E. Gionfriddo, J. Poole, et al., Anal. Chem. 89 (2017) 7240–7248. doi: 10.1021/acs.analchem.7b01553
10. [10]
  M. Dong, G. Wen, H. Tang, et al., Food Chem. 269 (2018) 136–141. doi: 10.1016/j.foodchem.2018.07.005
11. [11]
  J. Fenoll, P. Hellín, C. Marín, et al., J. Agric. Food Chem. 53 (2005) 7661–7666. doi: 10.1021/jf051327s
12. [12]
  X. Li, X. Gao, W. Shi, et al., Chem. Rev. 114 (2014) 590–659. doi: 10.1021/cr300508p
13. [13]
  M.H. Lee, J.S. Kim, J.L. Sessler, Chem. Soc. Rev. 44 (2015) 4185–4191. doi: 10.1039/C4CS00280F529-2
14. [14]
  Z. Xu, W. Deng, N. Li, et al., Chem. Commun. 60 (2024) 6304–6307. doi: 10.1039/d4cc01813c
15. [15]
  K. Li, T.B. Ren, S. Huan, et al., J. Am. Chem. Soc. 143 (2021) 21143–21160. doi: 10.1021/jacs.1c10925
16. [16]
  S. Xu, K.C. Yan, Z.H. Xu, et al., Chem. Soc. Rev. 53 (2024) 7590–7631. doi: 10.1039/d3cs00171g
17. [17]
  Z. Zheng, H. Yu, W.C. Geng, et al., Nat. Commun. 10 (2019) 5762. doi: 10.1038/s41467-019-13775-1
18. [18]
  Y. Zhao, Y. Mei, J. Sun, et al., J. Am. Chem. Soc. 147 (2025) 5025–5034. doi: 10.1021/jacs.4c14727
19. [19]
  N. Xue, H.Y. Zhou, Y. Han, et al., Nat. Commun. 15 (2024) 1425. doi: 10.1038/s41467-024-45717-x
20. [20]
  A.C. Sedgwick, J.T. Brewster, T. Wu, et al., Chem. Soc. Rev. 50 (2021) 9–38. doi: 10.1039/c9cs00538b
21. [21]
  T. Liu, X. Han, X. Sun, et al., Chin. Chem. Lett. 36 (2025) 110170. doi: 10.1016/j.cclet.2024.110170
22. [22]
  F. Zheng, R. Xiao, S. Huang, et al., Chin. Chem. Lett. 36 (2025) 109876. doi: 10.1016/j.cclet.2024.109876
23. [23]
  Z. Xiong, S. Qiu, Y. Wang, et al., Chin. Chem. Lett. 36 (2025) 110002. doi: 10.1016/j.cclet.2024.110002
24. [24]
  Z. Xu, Q. Zheng, N. Li, et al., J. Hazard. Mater. 477 (2024) 135364. doi: 10.1016/j.jhazmat.2024.135364
25. [25]
  J. Shang, X. Zhang, Z. He, et al., Angew. Chem. Int. Ed. 61 (2022) e202205043. doi: 10.1002/anie.202205043
26. [26]
  P. Xing, Y. Niu, R. Mu, et al., Nat. Commun. 11 (2020) 1573. doi: 10.1038/s41467-020-15323-8
27. [27]
  S. Linciano, G. Moro, A. Zorzi, et al., J. Control. Release 348 (2022) 115–126. doi: 10.1016/j.jconrel.2022.05.038
28. [28]
  Y. Wang, F. Huo, C. Yin, J. Phys. Chem. B 128 (2024) 1121–1138. doi: 10.1021/acs.jpcb.3c06915
29. [29]
  Z. Luo, T. Lv, K. Zhu, et al., Angew. Chem. Int. Ed. 59 (2020) 3131–3136. doi: 10.1002/anie.201915046
30. [30]
  M. Zhai, H.L. Wu, S.R. Zhang, et al., Sci. China Chem. 57 (2014) 748–754. doi: 10.1007/s11426-013-4987-5
31. [31]
  L. Wenskowsky, H. Schreuder, V. Derdau, et al., Angew. Chem. Int. Ed. 57 (2018) 1044–1048. doi: 10.1002/anie.201710437
32. [32]
  S. Curry, H. Mandelkow, P. Brick, et al., Nat. Struct. Biol. 5 (1998) 827–835. doi: 10.1038/1869
33. [33]
  Z. Xu, X. Zhao, M. Zhou, et al., Sens. Actuators B: Chem. 345 (2021) 130367. doi: 10.1016/j.snb.2021.130367
34. [34]
  C. Wang, Q. Qiao, W. Chi, et al., Angew. Chem. Int. Ed. 59 (2020) 10160–10172. doi: 10.1002/anie.201916357
35. [35]
  G. Rabbani, E.J. Lee, K. Ahmad, et al., Mol. Pharm. 15 (2018) 1445–1456. doi: 10.1021/acs.molpharmaceut.7b00976
36. [36]
  Z. Xu, C. Zeng, Y. Zhao, et al., Food Chem. 410 (2023) 135381. doi: 10.1016/j.foodchem.2022.135381
37. [37]
  C. Chen, M. Lin, C. Wahl, et al., J. Am. Chem. Soc. 145 (2023) 7974–7982. doi: 10.1021/jacs.2c13515
38. [38]
  M.S. Woolf, L.M. Dignan, A.T. Scott, et al., Nat. Protoc. 16 (2021) 218–238. doi: 10.1038/s41596-020-00413-0
39. [39]
  Y. Zhu, J. Wang, H. Xie, et al., Anal. Chem. 94 (2022) 10451–10461. doi: 10.1021/acs.analchem.2c01649
40. [40]
  S. Augustine, A. Venkadesh, S. Kaushal, et al., Anal. Chem. 97 (2025) 9569–9599. doi: 10.1021/acs.analchem.4c07075
41. [41]
  D.C. Christodouleas, B. Kaur, P. Chorti, ACS Cent. Sci. 4 (2018) 1600–1616. doi: 10.1021/acscentsci.8b00625
42. [42]
  N. Li, Z. Xu, Y. Chen, et al., Sens. Actuators B: Chem. (2024) 135823.
43. [43]
  H. Li, Q. Zhong, M. Wang, et al., J. Sci. Food Agr. 102 (2022) 3983–3993. doi: 10.1002/jsfa.11746
44. [44]
  European Food Safety Authority, EFSA J. 11 (2013) 3489.
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