Citation: Zhiyuan Huang, Fangqiu Fu, Chaoqiang Deng, Shiyang Wu, Mingxuan Huang, Xianyi Sha, Ming Q Wei, Zhiwen Zhang, Yang Zhang. Strategies of designing lymph nodes-targeting nanoparticles for cancer immunotherapy[J]. Chinese Chemical Letters, ;2026, 37(9): 111993. doi: 10.1016/j.cclet.2025.111993 shu

Strategies of designing lymph nodes-targeting nanoparticles for cancer immunotherapy

Zhiyuan Huang ^{a, b, c} ,
Fangqiu Fu ^{a, b, c} ,
Chaoqiang Deng ^{a, b, c} ,
Shiyang Wu ^d ,
Mingxuan Huang ^d ,
Xianyi Sha ^d ,
Ming Q Wei ^e ,
Zhiwen Zhang ^{d, *,} ,
Yang Zhang ^{a, b, c, *,}

a.
Department of Thoracic Surgery and State Key Laboratory of Genetics and Development of Complex Phenotypes, Fudan University Shanghai Cancer Center, Shanghai 200032, China
b.
Institute of Thoracic Oncology, Fudan University, Shanghai 200032, China
c.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
d.
School of Pharmaceutical Sciences, Key laboratory of smart drug delivery (Ministry of Education), State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai 201203, China
e.
Menzies Health Institute Queensland and School of Medical Science, Gold Coast Campus, Griffith University, Queensland 4222, Australia

zhangzhiwen@fudan.edu.cn

fduzhangyang1987@hotmail.com

Received Date: 8 June 2025
Revised Date: 20 October 2025
Accepted Date: 21 October 2025
Available Online: 21 October 2025

Figures(7)

Lymph nodes (LNs), as specialized secondary lymphoid organs with highly organized micro-architecture containing various immune cells, play a pivotal role in antigen presentation and immune cell activation. Compared to traditional immunotherapy delivery methods, LN-targeted delivery demonstrates greater effectiveness in modulating the immunosuppressive environment within tumor-draining lymph nodes (TDLNs), thereby activating anti-cancer immunity, and reducing potential systemic side effects. This review summarizes various types of LN-targeted nanoparticles (NPs) and factors influencing targeting efficiency as well as outlining recent advances in LN-targeted immunotherapeutic agents. It is expected that this review will provide a comprehensive understanding of the current research landscape and emerging trends in this field, offering guidance for future studies.
- Lymph node-targeted delivery,
- Tumor immunotherapy,
- Lymph nodes,
- Nanoparticles,
- Tumor microenvironment,
- Tumor immunology
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