Citation: Mingxiao Liu, Wenzhuo Zheng, Jianru Yi, Jiahe Li, Jiyao Li, Yi Deng, Fusong Yuan, Kunneng Liang, Zhihe Zhao. Synergistic photocatalysis and biochemical reactivity in MXene/CuO₂ nanofibrous membrane for enhanced sterilization and tissue regeneration in chronic skin wounds[J]. Chinese Chemical Letters, ;2026, 37(9): 111985. doi: 10.1016/j.cclet.2025.111985 shu

Synergistic photocatalysis and biochemical reactivity in MXene/CuO₂ nanofibrous membrane for enhanced sterilization and tissue regeneration in chronic skin wounds

Mingxiao Liu ^{a, 1} ,
Wenzhuo Zheng ^{a, 1} ,
Jianru Yi ^a ,
Jiahe Li ^a ,
Jiyao Li ^a ,
Yi Deng ^c ,
Fusong Yuan ^{b, *,} ,
Kunneng Liang ^{a, *,} ,
Zhihe Zhao ^{a, *,}

a.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China
b.
Center of Digital Dentistry/Department of Prosthodontics, National Clinical Research Center for Oral Diseases, Peking University School and Hospital of Stomatology, Beijing 100081, China
c.
School of Chemical Engineering, Sichuan University, Chengdu 610041, China

yuanfusong@bjmu.edu.cn

kunnengliang@scu.edu.cn

zhzhao@scu.edu.cn

Received Date: 9 June 2025
Revised Date: 16 October 2025
Accepted Date: 20 October 2025
Available Online: 21 October 2025

Figures(5)

Chronic skin wounds with persistent bacterial infections present a formidable clinical challenge, characterized by recurrent infections and delayed healing. These issues stem from incomplete bacterial eradication, a lack of sustained antibacterial ability, and slow tissue repair. We developed a dual-responsive nanocatalytic membrane to address these limitations for advanced infected chronic wound management. This platform integrates MXene/CuO₂ bio-heterojunctions (MX/CO bio-HJs) with polydopamine (PDA) and electrospun polycaprolactone (PCL) scaffolds, creating a multifunctional system that synergistically enhances debridement and regeneration. Diverging from traditional dressings, this membrane leverages near-infrared (NIR) light to trigger robust antibacterial action through synergistic photodynamic (PDT) and photothermal (PTT) therapies, ensuring complete sterilization. In the absence of NIR, it autonomously responds to the infection microenvironments (IMEs) by initiating Fenton-like cascades via chemodynamic therapy (CDT) and metal-ion therapy (MIT), sustaining reactive oxygen species (ROS) production and Cu²⁺ ions release to prevent recurrent infections. Simultaneously, the released Cu²⁺ ions enhance vascular endothelial growth factor (VEGF) expression, fostering angiogenesis and hastening wound closure, thus reducing infection risks linked to prolonged exposure. In vivo studies demonstrate rapid bacterial elimination, significant remodeling of the wound milieu, and enhanced epithelialization, collagen deposition, and vascularization. This innovative design overcomes the deficiencies of existing modalities, offering a NIR/IMEs dual-responsive approach to managing chronic infected wounds with precision and efficacy.
- Bio-heterojunctions,
- Phototherapy,
- Synergistically antibacterial,
- Angiogenesis,
- Wound healing
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Synergistic photocatalysis and biochemical reactivity in MXene/CuO2 nanofibrous membrane for enhanced sterilization and tissue regeneration in chronic skin wounds

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通讯作者: 陈斌, bchen63@163.com

Synergistic photocatalysis and biochemical reactivity in MXene/CuO₂ nanofibrous membrane for enhanced sterilization and tissue regeneration in chronic skin wounds