Citation: Li Yang, Yuhong Gong, Liqing Mo, Ting Zhu, Yingxuan Dai, Xinrui Hu, Yuxi Zhu, Yi Zhao, Jianhua He. Drug delivery systems for the treatment of venous thrombosis[J]. Chinese Chemical Letters, ;2026, 37(9): 111983. doi: 10.1016/j.cclet.2025.111983 shu

Drug delivery systems for the treatment of venous thrombosis

Li Yang ^{a, b, 1} ,
Yuhong Gong ^{a, b, 1} ,
Liqing Mo ^{a, b} ,
Ting Zhu ^{a, b} ,
Yingxuan Dai ^a ,
Xinrui Hu ^a ,
Yuxi Zhu ^{d, e} ,
Yi Zhao ^{c, *,} ,
Jianhua He ^{a, b, *,}

a.
School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China
b.
Hubei Shizhen Laboratory, Wuhan 430065, China
c.
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China
d.
Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH 43210, United States
e.
Department of Pediatrics, University Hospitals Rainbow Babies & Children’s Hospital, Cleveland, OH 44106, United States

zhaoy529@mail.sysu.edu.cn

jianhua11423@126.com

Received Date: 17 July 2025
Revised Date: 13 October 2025
Accepted Date: 16 October 2025
Available Online: 17 October 2025

Figures(2)

Venous thrombosis (VT) is defined by the formation of a blood clot within a vein, leading to partial or complete obstruction of blood flow. This condition may result in severe sequelae, including chronic thromboembolic pulmonary hypertension and post-thrombotic syndrome. As a multifactorial and episodic disorder, VT constitutes a significant contributor to global morbidity and mortality. In this review, we first seek to provide a comprehensive understanding of the intricate pathophysiological mechanisms underlying VT. Next, the diagnostic challenges posed by the nonspecific nature of clinical signs and symptoms were explored, offering an overview of current strategies aimed at enhancing diagnostic accuracy. Furthermore, treatment modalities for VT, primarily consisting of anticoagulation therapy, along with thrombolysis or surgical intervention when indicated, are discussed in detail. Considering the urgent need for safer and more effective therapeutic options, the development of nanoparticle-based drug delivery systems (DDS) capable of specific sites of thrombosis is crucial. Thus, this review further examines recent advancements in DDS for the treatment of VT. Finally, we will evaluate the prospects and significant challenges currently facing the field, offering a comprehensive overview of the research and treatment of VT.
- Venous thrombosis,
- Diagnosis,
- Anticoagulation,
- Drug delivery system,
- Nanoparticle
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沈阳化工大学材料科学与工程学院沈阳 110142