Citation: Lele Meng, Ruhe Zhang, Liying Wang, Yuanzheng Wang, Bo Li, Long Chen. Glucose/ROS dual-responsive hydrogel loaded with mangiferin accelerates diabetic wound healing[J]. Chinese Chemical Letters, ;2026, 37(9): 111981. doi: 10.1016/j.cclet.2025.111981 shu

Glucose/ROS dual-responsive hydrogel loaded with mangiferin accelerates diabetic wound healing

Lele Meng ^{a, b, 1} ,
Ruhe Zhang ^{c, 1} ,
Liying Wang ^{d, *,} ,
Yuanzheng Wang ^a ,
Bo Li ^a ,
Long Chen ^{a, b, *,}

a.
Department of Orthopedics, Guizhou Provincial People’s Hospital, Guiyang 550000, China
b.
College of Orthopedics and Traumatology, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
c.
Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China
d.
Department of Anesthesiology, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, China

wangly53@mail2.sysu.edu.cn

longchen@gzu.edu.cn

Received Date: 5 August 2025
Revised Date: 14 October 2025
Accepted Date: 16 October 2025
Available Online: 17 October 2025

Figures(4)

Diabetic wounds are characterized by local oxidative stress, bacterial infection, and persistent inflammation, all of which hinder effective clinical healing. To address these challenges, we developed a glucose/reactive oxygen species (ROS) dual-responsive hydrogel (hyaluronic acid-phenylboronic acid (HA-PBA)/polyvinyl alcohol (PVA)/mangiferin (MF), HPM) composed of HA-PBA and PVA. This hydrogel incorporates MF, a bioactive compound with multiple therapeutic properties, through dynamic boronate ester bonds, enabling stimulus-responsive drug release tailored to the diabetic wound microenvironment, thereby enhancing wound repair. Physicochemical analyses demonstrated that HPM exhibits a favorable porous structure, excellent swelling behavior, appropriate rheological characteristics, and self-healing capability. In vitro studies revealed that HPM effectively scavenges ROS, inhibits bacterial proliferation, attenuates inflammation, and promotes angiogenesis. In a diabetic rat model, HPM significantly accelerated wound closure, as indicated by enhanced epithelial regeneration, increased collagen deposition, improved neovascularization, and suppressed inflammatory. Moreover, biocompatibility evaluations confirmed the excellent biosafety of HPM both in vitro and in vivo. This multifunctional hydrogel dressing, combining glucose and ROS sensitivity with robust therapeutic efficacy and biocompatibility, offers a promising strategy for diabetic wound management.
- Diabetic wounds,
- Hydrogel,
- Mangiferin,
- Antioxidation,
- Anti-inflammatory
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沈阳化工大学材料科学与工程学院沈阳 110142