Citation: Bin Zhao, Wenyue Cui, Wenhao Huang, Zongsu Han, Zhonghang Chen, Peng Cheng, Wei Shi. Recyclable construction of chiral hydrogen-bonded frameworks via inducer-modulated spontaneous resolution for enantioselective sensing[J]. Chinese Chemical Letters, ;2026, 37(5): 111975. doi: 10.1016/j.cclet.2025.111975 shu

Recyclable construction of chiral hydrogen-bonded frameworks via inducer-modulated spontaneous resolution for enantioselective sensing

Bin Zhao ^a ,
Wenyue Cui ^a ,
Wenhao Huang ^a ,
Zongsu Han ^a ,
Zhonghang Chen ^a ,
Peng Cheng ^{a, b} ,
Wei Shi ^{a, *,}

a.
Frontiers Science Center for New Organic Matter, State Key Laboratory of Advanced Chemical Power Sources, and Department of Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
b.
Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China

shiwei@nankai.edu.cn

Received Date: 24 June 2025
Revised Date: 13 October 2025
Accepted Date: 15 October 2025
Available Online: 16 October 2025

Figures(4)

Spontaneous resolution is a way for constructing chiral compounds from achiral modules, but the products are usually stochastic, which is unsuitable for enantioselective applications. Herein, a pair of chiral hydrogen-bonded frameworks assembled from achiral modules was reported. By introducing reusable chiral inducers, enantiomerically enriched NKU-777-xD/xL were obtained and exhibited superior enantioselective sensing performance. Notably, the amount of chiral inducer shows a positive correlation with the enantioselective sensing function, reflecting the degree of enantiomeric excess of NKU-777-xD/xL. Molecular-level mechanism studies reveal that competitive absorption governs the sensing functions of NKU-777-xD/xL, and the enantioselectivity is due to the enantioselective interactions of the hydrogen-bonded frameworks with targeting chiral molecules. This work not only provides a facile way to synthesize enantiomerically enriched chiral hydrogen-bonded frameworks from achiral modules using reusable chiral inducer but also gains insights into the inducer-controlled enantiomerically enriched chiral compounds for enantioselective applications.
- Spontaneous resolution,
- Chiral induction,
- Inducer modulation,
- Hydrogen-bonded framework,
- Enantioselective sensing
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