Citation: Mo Zhang, Qingqing Dou, Ge Gao, Fan Xu, Siao Yang, Hongjin Lv, Jing Wang. A dual-functional polyoxomolybdate@COF nanoplatform for synergistic chemo-photodynamic tumor therapy[J]. Chinese Chemical Letters, ;2026, 37(12): 111953. doi: 10.1016/j.cclet.2025.111953 shu

A dual-functional polyoxomolybdate@COF nanoplatform for synergistic chemo-photodynamic tumor therapy

Mo Zhang ^a ,
Qingqing Dou ^a ,
Ge Gao ^a ,
Fan Xu ^a ,
Siao Yang ^a ,
Hongjin Lv ^{b, *,} ,
Jing Wang ^{a, *,}

a.
School of Pharmacy, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang 050017, China
b.
MOE Key Laboratory of Cluster Science, Beijing Key Laboratory of Photoelectric/Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China

hlv@bit.edu.cn

17200949@hebmu.edu.cn

Received Date: 2 September 2025
Revised Date: 30 September 2025
Accepted Date: 12 October 2025
Available Online: 13 October 2025

Figures(7)

The development of innovative drug delivery systems for POMs-based nanomedicines with enhanced targeting and efficient multi-modal therapeutic capabilities is crucial for tumor therapy. Herein, a novel POMo@COF-PEG nanoplatform by integrating mixed-valence polyoxomolybdate (POMo) into a photosensitive covalent organic framework (COF) has been successfully developed. This nanoplatform exhibited a synergistic COF-based photodynamic therapy effect and a POMo-based chemotherapy effect to induce cancer cell apoptosis. Various in vitro and in vivo studies including proteomic analysis and Western blot experiments demonstrated for the first time that the POMo could regulate the apoptosis signaling pathway by inhibiting the 4T1 cell proliferation via an apoptosis pathway. The present study provides valuable insights in developing novel polyoxometalate (POM)-based anti-tumor nanodrugs.
- Polyoxometalate,
- Antitumor mechanism,
- Apoptosis,
- Photodynamic therapy,
- Proteomic analysis
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