Citation: Jiaojiao Yang, Shaokun Yang, Wei Cheng, Jie Wu, Haijing Qu, Han Chen, Zhiran Duan, Yuqing Pan, Ning Wang, Chao Wang, Jian Gao, Bai Xiang, Xiangdong Xue. Self-assembled cyclodextrin-porphyrin nanoplatform for synergistic chemo-phototherapy and targeted delivery of camptothecin against breast cancer[J]. Chinese Chemical Letters, ;2026, 37(4): 111901. doi: 10.1016/j.cclet.2025.111901 shu

Self-assembled cyclodextrin-porphyrin nanoplatform for synergistic chemo-phototherapy and targeted delivery of camptothecin against breast cancer

Jiaojiao Yang ^{a, b, 1} ,
Shaokun Yang ^{a, b, 1} ,
Wei Cheng ^c ,
Jie Wu ^c ,
Haijing Qu ^c ,
Han Chen ^c ,
Zhiran Duan ^c ,
Yuqing Pan ^c ,
Ning Wang ^c ,
Chao Wang ^c ,
Jian Gao ^a ,
Bai Xiang ^{a, b, *,} ,
Xiangdong Xue ^{c, *,}

a.
Hebei Key Laboratory of Innovative Drug Research and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China
b.
National Key Laboratory of New Pharmaceutical Preparations and Excipients, Shijiazhuang 050017, China
c.
Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmaceutical Sciences, National Key Laboratory of Innovative Immunotherapy, Shanghai Jiao Tong University, Shanghai 200240, China

baixiang@hebmu.edu.cn

xuexd@sjtu.edu.cn

Received Date: 3 July 2025
Revised Date: 23 September 2025
Accepted Date: 25 September 2025
Available Online: 25 September 2025

Figures(5)

The management of breast cancer remains clinically intractable, driven by its highly invasive behavior and limited susceptibility to conventional treatments. In this study, we engineered an innovative cyclodextrin-porphyrin co-assembled nanoplatform (CT NPs) to enable multimodal breast cancer therapy. By successfully encapsulating camptothecin (CPT) within this nanocarrier, the system (CTC NPs) achieved synergistic chemo-phototherapeutic efficacy through dual-modality action. The highly biocompatible cyclodextrin carrier significantly improved the physicochemical characteristics of CPT. In vivo studies revealed that CTC NPs effectively evaded clearance by the reticuloendothelial system, overcame the defect of premature drug leakage, and exhibited superior tumor targeting and infiltration capabilities. Under near-infrared (NIR) laser irradiation, CTC NPs can simultaneously induce localized hyperthermia and produce reactive oxygen species (ROS), thereby achieving efficient tumor ablation. In 4T1 tumor-bearing mice, CTC NPs exhibited targeted, safe, and highly potent anti-tumor efficacy, significantly suppressing both primary tumor progression (tumor suppression rate > 95%) and metastatic dissemination. In summary, this integrated nanoplatform establishes a novel theranostic paradigm for synergistic chemo-phototherapy against triple-negative breast cancer (TNBC), achieving precise tumor ablation through NIR-triggered drug release and real-time imaging guidance.
- Breast cancer,
- Drug delivery,
- Camptothecin,
- PDT,
- PTT
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